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204376-54-5

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204376-54-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 204376-54-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,4,3,7 and 6 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 204376-54:
(8*2)+(7*0)+(6*4)+(5*3)+(4*7)+(3*6)+(2*5)+(1*4)=115
115 % 10 = 5
So 204376-54-5 is a valid CAS Registry Number.

204376-54-5Downstream Products

204376-54-5Relevant articles and documents

Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region)

Varie, David L.,Shih, Chuan,Hay, David A,Andis, Sherri L.,Corbett, Tom H.,Gossett, Lynn S.,Janisse, Samantha K.,Martinelli, Michael J.,Moher, Eric D.,Schultz, Richard M.,Toth, John E.

, p. 369 - 374 (2007/10/03)

Analogs of the antitumor agents cryptophycins 1 and 8 with dialkyl substitution at C-6 (fragment C) were synthesized and evaluated for in vitro cytotoxicity against human leukemia cells (CCRF-CEM). The activity of these analogs decreased as the size of the substituents at C-6 increased. The C-6 spirocylopropyl compound (2g) was highly potent in vitro and showed excellent antitumor activity in animal models.

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