20442-66-4

Basic information

• Product Name: 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE
• Synonyms: 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE
• CAS NO: 20442-66-4
• Molecular Formula: C₁₆H₁₂O₂
• Molecular Weight: 236.26528
• Mol File: 20442-66-4.mol
• Article Data: 116

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE(20442-66-4)
• EPA Substance Registry System: 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE(20442-66-4)

Safety Data

• Hazardous Substances Data: 20442-66-4(Hazardous Substances Data)

Upstream product

• 129972-88-9 (benzoyliodomethyl)triphenylphosphonium iodide 
• 123-11-5 4-methoxy-benzaldehyde 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 536-74-3 phenylacetylene 
• 98-88-4 benzoyl chloride 
• 289473-23-0 diphenyl(p-methoxyphenylethynyl)stibine 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 603-36-1 triphenylantimony 
• 355116-21-1 (4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone 
• 591-50-4 iodobenzene 
• 768-60-5 4-methoxyphenylacetylen 
• 951025-61-9 C₁₉H₁₉NO 
• 951025-54-0 C₁₉H₂₁Cl₂NO 

Downstream Products

• 3672-51-3 5-(4-methoxyphenyl)-3-phenylisoxazole 
• 3672-52-4 3-(4-methoxyphenyl)-5-phenylisoxazole 
• 15026-62-7 [2-(di-morpholin-4-yl-methylene)-5-(4-methoxy-phenyl)-[1,3]dithiol-4-yl]-phenyl-methanone 
• 86175-38-4 (Z)-3-(4-Methoxy-phenyl)-1-phenyl-3-p-tolylsulfanyl-propenone 
• 144459-28-9 (Z)-3-(4-Amino-4H-[1,2,4]triazol-3-ylsulfanyl)-3-(4-methoxy-phenyl)-1-phenyl-propenone 
• 38468-90-5 4-(4-methoxyphenyl)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile 
• 80214-06-8 N'-[1-(4-Methoxy-phenyl)-3-oxo-3-phenyl-prop-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester 
• 80214-08-0 N'-[1-(4-Methoxy-phenyl)-3-oxo-3-phenyl-prop-(E)-ylidene]-hydrazinecarboxylic acid phenyl ester 
• 29784-23-4 (E)-3-(4-Methoxy-phenyl)-1-phenyl-3-p-tolylamino-propenone 
• 7121-43-9 α,β-dibromo-4-methoxy-chalcone 
• 33045-40-8 3-p-anisyl-1,5-diphenylpyrazole 
• 66870-45-9 5-(4-methoxyphenyl)-1-methyl-3-phenyl-1H-pyrazole 
• 56119-91-6 3-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole 
• 705255-91-0 3-(4-methoxyphenyl)-1H-inden-1-one 

Relevant articles and documents

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Electrochemical Palladium-Catalyzed Oxidative Sonogashira Carbonylation of Arylhydrazines and Alkynes to Ynones

Oxidative carbonylation using carbon monoxide has evolved as an attractive tool to valuable carbonyl-containing compounds, while mixing CO with a stoichiometric amount of a chemical oxidant especially oxygen is hazardous and limits its application in scale-up synthesis. By employing anodic oxidation, we developed an electrochemical palladium-catalyzed oxidative carbonylation of arylhydrazines with alkynes, which is regarded as an alternative supplement of the carbonylative Sonogashira reaction. Combining an undivided cell with constant current mode, oxygen-free conditions avoids the explosion hazard of CO. A diversity of ynones are efficiently obtained using accessible arylhydrazines and alkynes under copper-free conditions. A possible mechanism of the electrochemical Pd(0)/Pd(II) cycle is rationalized based upon cyclic voltammetry, kinetic studies, and intermediates experiments.

One-Pot Palladium-Catalyzed Carbonylative Sonogashira Coupling using Carbon Dioxide as Carbonyl Source

Carbonylation coupling reaction has emerged as a powerful and versatile strategy for the construction of carbonyl-containing compounds in modern synthetic chemistry over the past years. Carbon dioxide, a renewable one carbon molecule, has become one of the most attractive and promising alternative carbonyl sources due to its highly abundance, nontoxicity and stability in comparison with CO in recent years. However, in most cases, a two-chamber technique was generally necessary to allow the CO-producing and CO-consuming processes to perform successfully because of the complexities and incompatibility of reaction conditions, when carbon dioxide was utilized as carbonyl source. Herein, a practical one-pot protocol using carbon dioxide as the carbonyl source for the palladium-catalyzed carbonylative Sonogashira coupling has been established, providing an expedient and practical route to a wide range of functionalized alkynones and indoxyls under mild reaction conditions. By finding a suitable catalytic system, the method allowed the CO-generating and CO-consuming processes to proceed in one pot, wherein carbon monoxide was generated in situ from the reduction of carbon dioxide in the absence of any fluoride reagents. Simple and safe operation, readily available substrates, good functional group tolerance and mild reaction conditions are the features of the method.