204516-31-4

Basic information

• Product Name: 2-(trifluoromethyl)-4H-pyran-4-one
• Synonyms: 2-(trifluoromethyl)-4H-pyran-4-one
• CAS NO: 204516-31-4
• Molecular Formula: C6H3F3O2
• Molecular Weight: 164.082
• EINECS: 200-258-5
• Mol File: 204516-31-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 21℃
• Boiling Point: 154℃
• Flash Point: 46℃
• Appearance: /
• Density: 1.469
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(trifluoromethyl)-4H-pyran-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(trifluoromethyl)-4H-pyran-4-one(204516-31-4)
• EPA Substance Registry System: 2-(trifluoromethyl)-4H-pyran-4-one(204516-31-4)

Safety Data

• Hazardous Substances Data: 204516-31-4(Hazardous Substances Data)

Usage

General Description

2-(trifluoromethyl)-4H-pyran-4-one is a chemical compound with the molecular formula C6H3F3O2. It is a heterocyclic compound that contains a pyran ring with a trifluoromethyl group attached at the 2-position. 2-(trifluoromethyl)-4H-pyran-4-one is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including its anti-inflammatory and antimicrobial properties. Additionally, its unique structural features make it a valuable starting material for the synthesis of more complex organic molecules.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 51731-17-0 trans-4-methoxy-3-buten-2-one 
• 1000350-06-0 4-oxo-6-(trifluoromethyl)-4H-pyran-2-carboxylic acid 
• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 431-47-0 trifluoroacetic acid-methyl ester 

Downstream Products

• 170886-13-2 4-hydroxy-2-trifluoromethylpyridine 
• 1363422-02-9 2-(trifluoromethyl)-3-(1-phenyl-1H-pyrazol-5-yl)-1H-indole 
• 1363422-05-2 2-(trifluoromethyl)-3-(1-phenyl-1H-pyrazol-3-yl)-1H-indole 
• 1620579-54-5 3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde 
• 1620579-55-6 (3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)phenyl)methanol 
• 1620578-11-1 (S)-7-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one 
• 1620578-12-2 7-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one 
• 1620578-97-3 (S)-7-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one 
• 1620579-10-3 (R)-7-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one 

Relevant articles and documents

ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES

The application relates to 2-imino-hexahydropyrimidin-4-one derivatives of formula (I) which are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful for the treatment of malaria.

2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

2,3-DIHYDROIMIDAZO[1,2-C] PYRIMIDIN-5(1H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS

Disclosed are 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one compounds that inhibit Lp-PLA2, processes for their preparation, compositions containing them and their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer?s disease