204589-80-0 Usage
Description
Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate is a complex organic compound with a unique molecular structure. It is characterized by its fluorophenyl and phenylmethoxyphenyl moieties, which contribute to its chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate is used as a reagent for the synthesis of antihypercholesterolemia drug ezetimibe. Its unique structure allows it to play a crucial role in the development of this medication, which is designed to help lower cholesterol levels in patients with high cholesterol or other heart disease risk factors.
Check Digit Verification of cas no
The CAS Registry Mumber 204589-80-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,4,5,8 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 204589-80:
(8*2)+(7*0)+(6*4)+(5*5)+(4*8)+(3*9)+(2*8)+(1*0)=140
140 % 10 = 0
So 204589-80-0 is a valid CAS Registry Number.
InChI:InChI=1/C26H24FNO4/c1-31-24(29)16-15-23-25(28(26(23)30)21-11-9-20(27)10-12-21)19-7-13-22(14-8-19)32-17-18-5-3-2-4-6-18/h2-14,23,25H,15-17H2,1H3/t23-,25-/m1/s1
204589-80-0Relevant articles and documents
Formal Synthesis of Ezetimibe Using a Proline-mediated, Asymmetric, Three-component Mannich Reaction
Shimasaki, Yasuharu,Koshino, Seitaro,Hayashi, Yujiro
, p. 30 - 32 (2016/01/20)
The formal total synthesis of ezetimibe was accomplished using a proline-mediated, asymmetric, three-component Mannich reaction as the key step. The two stereogenic centers on the β-lactam skeleton of ezetimibe were controlled by the syn-selective asymmetric Mannich reaction, followed by isomerization.
IMPROVED PROCESS FOR THE PREPARATION OF EZETIMIBE AND ITS INTERMEDIATES
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Page/Page column 18, (2008/06/13)
The present invention provides an improved process for the preparation of ezetimibe through novel organic amine salt compounds of general formula (1). The present invention also relates to a highly pure ezetimibe and 3-((3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-(benzyloxy)phenyl) azetidin-3-yl)propionic acid compound.
IMPROVED PROCESS FOR THE PREPARATION OF EZETIMIBE
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Page/Page column 12, (2008/06/13)
The present invention relates to a cost effective and industrially advantageous process for the preparation of (3R,4S)-l-(4-Fluorophenyl)-3-[3(S)-3-(4-fluorophenyl)-3 - hydroxypropyl)]-4-(4-hydroxyρhenyl)-2-azetidinone, referred to here as Ezetimibe, it is represented as formula (1).