204708-11-2

Basic information

• Product Name: (E)-1,1,1-trifluoro-4-(3-methoxyphenyl)but-3-en-2-one
• Synonyms: (E)-1,1,1-trifluoro-4-(3-methoxyphenyl)but-3-en-2-one
• CAS NO: 204708-11-2
• Molecular Weight: 230.186
• Mol File: 204708-11-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-1,1,1-trifluoro-4-(3-methoxyphenyl)but-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1,1,1-trifluoro-4-(3-methoxyphenyl)but-3-en-2-one(204708-11-2)
• EPA Substance Registry System: (E)-1,1,1-trifluoro-4-(3-methoxyphenyl)but-3-en-2-one(204708-11-2)

Safety Data

• Hazardous Substances Data: 204708-11-2(Hazardous Substances Data)

Upstream product

• 6099-04-3 trans-3-methoxycinnamic acid 
• 38693-90-2 trans-3-(3-methoxyphenyl)acrylic acid methyl ester 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 683-08-9 Diethyl methylphosphonate 
• 61881-19-4 2,2,2-trifluoro-N-phenyl-acetimidoyl chloride 
• 591-31-1 3-methoxy-benzaldehyde 
• 2398-37-0 3-methoxyphenyl bromide 
• 127223-93-2 (E)-4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one 
• 1267276-53-8 1,1,1-trifluoro-4-(3-methoxyphenyl)butan-2-one 

Downstream Products

• 1227671-22-8 1,1,1-trifluoro-4-(1H-indol-3-yl)-4-(3-methoxyphenyl)butan-2-one 
• 933996-69-1 4-(3-methoxyphenyl)-2-(4-methoxyphenyl)-6-(trifluoromethyl)-1,4-dihydropyridine-3-carbonitrile 
• 933996-64-6 4-(3-methoxyphenyl)-2-phenyl-6-(trifluoromethyl)-1,4-dihydropyridine-3-carbonitrile 

Relevant articles and documents

Evaluating aryl esters as bench-stable C(1)-ammonium enolate precursors in catalytic, enantioselective Michael addition-lactonisations

An evaluation of a range of aryl, alkyl and vinyl esters as prospective C(1)-ammonium enolate precursors in enantioselective Michael addition-lactonisation processes with (E)-trifluoromethylenones using isothiourea catalysis is reported. Electron deficient aryl esters are required for reactivity, with 2,4,6-trichlorophenyl esters providing optimal product yields. Catalyst screening showed that tetramisole was the most effective isothiourea catalyst, giving the desired dihydropyranone product in excellent yield and stereoselectivity (up to 90 : 10 dr and 98 : 2 er). The scope and limitations of this process have been evaluated, with a range of diester products being generated after ring-opening with MeOH to give stereodefined dihydropyranones with excellent stereocontrol (10 examples, typically ～90 : 10 dr and >95 : 5 er).

Dy(OTf)3/Pybox-catalyzed enantioselective Friedel-Crafts alkylation of indoles with α,β-unsaturated trifluoromethyl ketones

The first catalytic enantioselective Friedel-Crafts alkylation of indoles with α,β-unsaturated trifluoromethyl ketones has been accomplished. The reaction was achieved in the presence of the Dy(OTf)3/Pybox complex, producing the desired product