204718-94-5

Basic information

• Product Name: (2S,3S)-1,4-Bis-((S)-4-isobutyl-2-oxo-oxazolidin-3-yl)-2,3-diphenyl-butane-1,4-dione
• Synonyms: (2S,3S)-1,4-Bis-((S)-4-isobutyl-2-oxo-oxazolidin-3-yl)-2,3-diphenyl-butane-1,4-dione
• CAS NO: 204718-94-5
• Molecular Weight: 520.626
• Mol File: 204718-94-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-1,4-Bis-((S)-4-isobutyl-2-oxo-oxazolidin-3-yl)-2,3-diphenyl-butane-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-1,4-Bis-((S)-4-isobutyl-2-oxo-oxazolidin-3-yl)-2,3-diphenyl-butane-1,4-dione(204718-94-5)
• EPA Substance Registry System: (2S,3S)-1,4-Bis-((S)-4-isobutyl-2-oxo-oxazolidin-3-yl)-2,3-diphenyl-butane-1,4-dione(204718-94-5)

Safety Data

• Hazardous Substances Data: 204718-94-5(Hazardous Substances Data)

Upstream product

• 103-80-0 phenylacetyl chloride 
• 17016-85-2 (S)-(-)-4-isobutyloxazolidin-2-one 
• 204718-93-4 (S)-4-Isobutyl-3-phenylacetyl-oxazolidin-2-one 

Relevant articles and documents

Asymmetric synthesis of optically active 2,3-diarylsuccinic acids by oxidative homocoupling of chiral 3-(arylacetyl)-2-oxazolidones

Oxidative homocoupling of chiral 3-(arylacetyl)-2-oxazolidones 1 was achieved by treatment with DABCO-TiCl4 or DMAP-TiCl4 and afforded the corresponding dimers stereospecifically. The reaction of (4S)- and (4R)-substituted 1 gave (S,S)- and (R,R)-dimers respectively. The obtained dimers were easily transformed to the corresponding 2,3-diaryl succinic acids. This reaction therefore provides a useful method For the synthesis of optically pure 2,3-diarylsuccinic acids. The oxidative coupling was not inhibited by para substitution of an electron donating group on the aryl group. A para-substituted electron withdrawing group and an ortho-substituent, however, hindered the coupling.