204777-78-6 Usage
Description
Fmoc-Lys(IVDDE)-OH is a FMOC (9H-fluoren-9-ylmethoxycarbon) and N-IVDDE (1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butyl) double protected amino acid (lysine). It plays a crucial role in peptide manufacturing and is particularly important for the production of peptides that require modification on the lysine side chain.
Uses
Used in Pharmaceutical Industry:
Fmoc-Lys(IVDDE)-OH is used as a building block for the synthesis of peptides with selective modifications on the lysine side chain. This is essential for the development of various pharmaceutical compounds, including labeled peptides, PEGylated peptides, and peptides cyclized through the lysine side chain.
Used in Research and Development:
Fmoc-Lys(IVDDE)-OH is used as a research tool for the study of peptide synthesis and modification. Its unique properties, such as the orthogonality of the IVDDE protective group compared to Boc and Fmoc, make it a valuable asset in the development of new peptide-based therapeutics and diagnostic tools.
Used in Drug Delivery Systems:
Fmoc-Lys(IVDDE)-OH is used in the manufacturing of anionic cell-penetrating peptides, which are essential for the intracellular delivery of therapeutic agents such as proteins and nucleic acids. The IVDDE group can be conveniently removed using hydrazine in the presence of acid-labile groups, allowing for precise control over the peptide's properties and function.
Chemical Properties:
Fmoc-Lys(IVDDE)-OH is a white to pale yellow powder, which is a common appearance for many amino acid derivatives and protected amino acids.
References
Wen-Qu, L. I., X. U. Hong-Yan, and L. I. Zhan-Xiong. "Synthesis of End N-Ivdde Protected Amino Acid."Chinese Journal of Synthetic Chemistry 17.2(2009):213-215.
http://www.chempep.com/ChemPep_Products2_Fmoc-Amino-Acid.php?id=101224
Chen, Hui Ting, et al. "Anionic cell penetrating peptide and its use for intracellular delivery." US, US8614194. 2013.
Check Digit Verification of cas no
The CAS Registry Mumber 204777-78-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,4,7,7 and 7 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 204777-78:
(8*2)+(7*0)+(6*4)+(5*7)+(4*7)+(3*7)+(2*7)+(1*8)=146
146 % 10 = 6
So 204777-78-6 is a valid CAS Registry Number.
InChI:InChI=1/C34H42N2O6/c1-21(2)17-28(31-29(37)18-34(3,4)19-30(31)38)35-16-10-9-15-27(32(39)40)36-33(41)42-20-26-24-13-7-5-11-22(24)23-12-6-8-14-25(23)26/h5-8,11-14,21,26-27,35H,9-10,15-20H2,1-4H3,(H,36,41)(H,39,40)/t27-/m0/s1
204777-78-6Relevant articles and documents
Photogenerated reagents
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Page/Page column 20, (2008/06/13)
This invention describes reagent precursors and methods for chemical and biochemical reactions. These reagent precursors that can be activated in solution upon irradiation to generate reagents required for the subsequent chemical reactions. Specifically, photogenerated reagents (PGR) are useful for controlling parallel combinatorial synthesis and various chemical and biochemical reactions.
