20488-28-2

Basic information

• Product Name: Pro-Pro-OH
• Synonyms: 1-Prolylproline;L-Pro-L-Pro-OH;N-(L-Prolyl)-L-proline;N-Prolylproline;Pro-Pro-OH
• CAS NO: 20488-28-2
• Molecular Formula: C₁₀H₁₆N₂O₃
• Molecular Weight: 212.2456
• Mol File: 20488-28-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 449.9°Cat760mmHg
• Flash Point: 225.9°C
• Appearance: /
• Density: 1.293g/cm³
• Vapor Pressure: 2.39E-09mmHg at 25°C
• Refractive Index: 1.552
• PKA: 3.19±0.20(Predicted)
• CAS DataBase Reference: Pro-Pro-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Pro-Pro-OH(20488-28-2)
• EPA Substance Registry System: Pro-Pro-OH(20488-28-2)

Safety Data

• Hazardous Substances Data: 20488-28-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 4005, 1989 DOI: 10.1021/jo00277a054

InChI:InChI=1/C10H16N2O3/c13-9(7-3-1-5-11-7)12-6-2-4-8(12)10(14)15/h7-8,11H,1-6H2,(H,14,15)

Upstream product

• 15401-08-8 N-tert-butoxycarbonyl-L-prolyl-L-proline 
• 57294-42-5 C₂₅H₂₈N₂O₅ 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 129223-22-9 Fmoc-L-Pro-Pro-OH 
• 84890-94-8 (S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 52386-41-1 N-tert-butoxycarbonyl-L-prolyl-L-proline methyl ester 
• 3261-70-9 N-trifluoroacetyl-L-prolyl-L-proline methyl ester 
• 6708-06-1 (5aS,10aS)-octahydrodipyrrolo[1,2-a:1',2'-d]pyrazine-5,10-dione 

Downstream Products

• 91474-70-3 Boc-Asp(OBzl)-Pro-Pro-OH 
• 36760-81-3 benzyloxycarbonyl-nitroarginyl-prolyl-proline 
• 75893-20-8 Z-Ala-Pro-Pro-Pro-OH 
• 88574-80-5 N-benzyloxycarbonyl-L-threonyl-N^ε-benzyloxycarbonyl-L-lysyl-L-prolyl-L-proline 
• 19285-44-0 Pro-Pro-Pro 
• 73535-22-5 Z-Gly-Pro-Pro-NH-NH-Boc 
• 74105-27-4 benzyloxycarbonyl-nitroarginyl-prolyl-proline pentachlorophenyl ester 
• 63-91-2 L-phenylalanine 
• 147-85-3 L-proline 

Relevant articles and documents

Synthesis of Prolylproline

Prolylproline has been synthesized by both classical peptide synthesis method utilizing tert-butoxycarbonyl or trifluoroacetyl protection of the NH group and carbodiimide-promoted peptide bond formation and by opening of the dioxopiperazine ring in octahydrodipyrrolo[1,2-a:1′,2′-d]pyrazine-5,10-dione obtained by thermolysis of proline methyl ester.

STUDIES OF BITTER PEPTIDES FROM CASEIN HYDROLYZATE - VII. BITTERNESS OF THE RETRO-BPIa (VAL-ILE-PHE-PRO-PRO-GLY-ARG) AND ITS FRAGMENTS.

To explain the bitter taste exhibited by BPIa (Arg-Gly-Pro-Pro-Phe-Ile-Val) which was isolated from casein hydrolyzate, the authors propose the following requirement: its characteristic spatial structure: the basic moiety in the N-terminal and the hydroph