204975-79-1

Basic information

• Product Name: Benzaldehyde, 2-hydroxy-5-methyl-3-(1-phenylethyl)-
• CAS NO: 204975-79-1
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• Mol File: 204975-79-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2-hydroxy-5-methyl-3-(1-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-hydroxy-5-methyl-3-(1-phenylethyl)-(204975-79-1)
• EPA Substance Registry System: Benzaldehyde, 2-hydroxy-5-methyl-3-(1-phenylethyl)-(204975-79-1)

Safety Data

• Hazardous Substances Data: 204975-79-1(Hazardous Substances Data)

Upstream product

• 106-44-5 p-cresol 
• 100-42-5 styrene 
• 50-00-0 formaldehyd 
• 1817-67-0 4-methyl-2-(1-phenylethyl)phenol 

Downstream Products

• 1582788-15-5 bis[4-methyl-2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(1-phenylethyl)phenoxy]titanium(IV) dichloride 
• 1582788-02-0 4-methyl-2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(1-phenylethyl)phenol 
• 496866-13-8 (R)-2-hydroxy-5-methyl-3-(1-phenylethyl)benzaldehyde 

Relevant articles and documents

Design of postmetallocene catalytic systems of arylimine type for olefin polymerization: XVI. Synthesis of (N-aryl)salicylaldimines containing pent-4-enyloxy group and their complexes with titanium(IV) dichloride

Reactions of p-(pent-4-enyloxy)aniline with salicylaldehyde containing versatile substituents in the positions 3 and 5 in an open system without solvent at 130°C afforded a series of (N-aryl)salicylaldimines, which with TiCl2(OPr-i)2 formed complexes of titanium(IV) dichloride L2TiCl2.

Synthesis and configurational assignment of chiral salicylic aldehydes: Novel building blocks for asymmetric catalysis

We report the synthesis of three novel and chiral salicylic aldehyde building blocks 6-8, each in both enantiomerically pure forms. Two of these salicylic aldehydes were prepared from (+)-camphene and each bear a [2.2.1]bicycloheptyl substituent ortho to the salicylic hydroxy group. In the third case, the chiral element at the 6-position is a (1-phenylethyl) group. The synthetic sequences consisted of ortho-alkylation of para-cresol with either camphene or styrene and subsequent ortho-formylation of the product phenols, The chromatographic separation of enantiomers was accomplished through the diastereomeric imines obtained from condensation of the racemic salicylic aldehydes with (R)-phenylglycinol. Finally, the absolute configurations of two of the salicylic aldehydes were established by X-ray crystallography. For this purpose, the (1-phenylethyl)-substituted salicylic aldehyde was condensed with L-valinamide, and the relative configuration of the resulting Schiff base diastereomer 12 was determined. In the second case, the racemic intermediate phenol rac-15 was separated by HPLC on a chiral stationary phase, ortho-brominated, and analyzed by anomalous X-ray scattering. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.