20498-68-4

Basic information

• Product Name: α-Phenyl-4-methylbenzeneethanol
• Synonyms: 1-Phenyl-2-(p-tolyl)ethanol;1-Phenyl-2-p-tolylethanol;α-Phenyl-4-methylbenzeneethanol
• CAS NO: 20498-68-4
• Molecular Formula: C₁₅H₁₆O
• Molecular Weight: 212.29
• Mol File: 20498-68-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: α-Phenyl-4-methylbenzeneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: α-Phenyl-4-methylbenzeneethanol(20498-68-4)
• EPA Substance Registry System: α-Phenyl-4-methylbenzeneethanol(20498-68-4)

Safety Data

• Hazardous Substances Data: 20498-68-4(Hazardous Substances Data)

Upstream product

• 96-09-3 styrene oxide 
• 2417-95-0 p-tolyllithium 
• 2430-99-1 1-phenyl-2-p-tolylethanone 
• 14310-20-4 4-methylbibenzyl 
• 29875-07-8 (4-methylbenzyl)magnesium chloride 
• 100-52-7 benzaldehyde 
• 100-42-5 styrene 
• 5395-43-7 tri(p-tolyl)antimony 
• 34921-09-0 diethyl (4-methylbenzyl) phosphate 
• 538-39-6 1,2-di-p-tolylethane 
• 4714-21-0 4-methylstilbene 
• 20498-63-9 1-(4-methylphenyl)-2-phenylethanol 
• 6335-83-7 4-(2-phenylethyl)phenol 
• 3839-46-1 stilben-4-ol 

Downstream Products

• 4714-15-2 1-Chloro-1-phenyl-2-p-tolylethan 
• 1016896-30-2 (R)-1-acetoxy-1-phenyl-2-(p-tolyl)ethane 
• 1422191-19-2 (S)-1-butyryloxy-1-phenyl-2-(4-methylphenyl)ethane 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Cobalt Catalyst Determines Regioselectivity in Ring Opening of Epoxides with Aryl Halides

Ring-opening of epoxides furnishing either linear or branched products belongs to the group of classic transformations in organic synthesis. However, the regioselective cross-electrophile coupling of aryl epoxides with aryl halides still represents a key challenge. Herein, we report that the vitamin B12/Ni dual-catalytic system allows for the selective synthesis of linear products under blue-light irradiation, thus complementing methodologies that give access to branched alcohols. Experimental and theoretical studies corroborate the proposed mechanism involving alkylcobalamin as an intermediate in this reaction.

Ni-catalysed regioselective 1,2-diarylation of unactivated olefins by stabilizing Heck intermediates as pyridylsilyl-coordinated transient metallacycles

We report a Ni-catalysed diarylation of unactivated olefins in dimethylpyridylvinylsilane by intercepting Heck C(sp3)-NiX intermediates, derived from aryl halides, with arylzinc reagents. This approach utilizes a modifiable pyridylsilyl moiety as a coordinating group that plays a dual role of intercepting oxidative addition species to promote Heck carbometallation, and stabilizing the Heck C(sp3)-NiX intermediates as transient metallacycles to suppress β-hydride elimination, and facilitate transmetalation/reductive elimination. This method affords 1,2-diarylethylsilanes, which can be readily oxidized to 1,2-diarylethanols that occur as structural motifs in 3-aryl-3,4-dihydroisocoumarin and dihydrostilbenoid natural products.

Catalytic functionalization of methyl group on silicon: Iridium-catalyzed C(sp3)-H borylation of methylchlorosilanes

A methyl group of methylchlorosilanes undergoes C-H borylation in an iridium-catalyzed reaction with bis(pinacolato)diboron in cyclohexane at 80 °C, giving (borylmethyl)chlorosilanes selectively.