205064-03-5

Basic information

• Product Name: (R)-2-tert-Butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid benzyl ester
• Synonyms: (R)-2-tert-Butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid benzyl ester
• CAS NO: 205064-03-5
• Molecular Weight: 481.33
• Mol File: 205064-03-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-tert-Butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-tert-Butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid benzyl ester(205064-03-5)
• EPA Substance Registry System: (R)-2-tert-Butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid benzyl ester(205064-03-5)

Safety Data

• Hazardous Substances Data: 205064-03-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 176199-35-2 (R)-2-((tert-butoxycarbonyl)amino)-3-(4-iodophenyl)propanoic acid 
• 62561-75-5 (R)-2-amino-3-(4-iodophenyl)propanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 205064-05-7 (Z)-3-[4-((R)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-phenyl]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-acrylic acid methyl ester 

Relevant articles and documents

Synthesis of optically active arylene bis-alanine derivatives carrying orthogonal protecting groups

Derivatives of para- and meta-phenylene bis-alanine and related biphenyl systems, carrying four orthogonal protecting groups, were synthesised via combinations of Heck couplings and asymmetric hydrogenations. The intermediate unsaturated arylalanine derivatives were hydrogenated using [Rh(COD)((R,R)-DIPAMP)]+BF4- or [Rh(COD)(Me-DuPHOS)]+X- as catalysts to produce the optically active, protected amino acid derivatives in ≤98% e.e. as analysed by chiral phase HPLC.