20518-58-5

Basic information

• Product Name: 3,3-bis(4-hydroxyphenyl)-5-methoxyindolin-2-one
• Synonyms: 3,3-bis(4-hydroxyphenyl)-5-methoxyindolin-2-one
• CAS NO: 20518-58-5
• Molecular Weight: 347.37
• Mol File: 20518-58-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,3-bis(4-hydroxyphenyl)-5-methoxyindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-bis(4-hydroxyphenyl)-5-methoxyindolin-2-one(20518-58-5)
• EPA Substance Registry System: 3,3-bis(4-hydroxyphenyl)-5-methoxyindolin-2-one(20518-58-5)

Safety Data

• Hazardous Substances Data: 20518-58-5(Hazardous Substances Data)

Upstream product

• 39755-95-8 5-methoxyisatine 
• 108-95-2 phenol 

Relevant articles and documents

Lambert Salt-Initiated Development of Friedel–Crafts Reaction on Isatin to Access Distinct Derivatives of Oxindoles

Herein, a mild metal-free and efficacious route for the synthesis of biologically important 3-aryl oxindole derivatives is described. Using Lambert salt-initiated hydroarylation of isatin, a diverse array of monoarylated products, symmetrical/unsymmetrical double-arylated products, and deoxygenated hydroarylated products could be synthesized from the single starting substrate in good to excellent yields. A preliminary mechanistic study revealed that the reaction proceeds via a monoarylated product followed by a nucleophilic attack by another electron-rich arene nucleophile under mild conditions. The potential of newly synthesized symmetric/unsymmetric 3,3-disubstituted oxindole, 3-substituted 3-hydroxy oxindoles, 3,3-di(indolyl)indolin-2-ones, and α-aryl oxindoles as valuable building blocks is further illustrated.

DIPHENYL OX-INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER

The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the preparation of a medicament for the treatment of cancer in a mammal. It is postulated that treatment of cancers in which inh