205194-11-2

Basic information

• Product Name: 3-Piperidinemethanol,1-methyl-,(3R)-(9CI)
• Synonyms: 3-Piperidinemethanol,1-methyl-,(3R)-(9CI);(R)-1-Methyl-3-(hydroxymethyl)piperidine;[(R)-1-Methylpiperidin-3-yl]methanol;3-Piperidinemethanol, 1-methyl-, (3R)-;(R)-3-Hydroxymethyl-1-methylpiperidine
• CAS NO: 205194-11-2
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2
• Product Categories: AMINETERTIARY
• Mol File: 205194-11-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 142.5°C at 760 mmHg
• Flash Point: 94.4°C
• Appearance: /
• Density: 0.949g/cm³
• Vapor Pressure: 2.26mmHg at 25°C
• Refractive Index: 1.464
• CAS DataBase Reference: 3-Piperidinemethanol,1-methyl-,(3R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinemethanol,1-methyl-,(3R)-(9CI)(205194-11-2)
• EPA Substance Registry System: 3-Piperidinemethanol,1-methyl-,(3R)-(9CI)(205194-11-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 205194-11-2(Hazardous Substances Data)

Usage

General Description

3-Piperidinemethanol, 1-methyl-, (3R)-(9CI) is a chemical compound with the molecular formula C6H13NO. It is a chiral compound, meaning it has a non-superimposable mirror image. 3-Piperidinemethanol,1-methyl-,(3R)-(9CI) is a derivative of piperidine and is mainly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It can undergo various chemical reactions to produce different derivatives, making it a versatile compound for the production of a wide range of products. Additionally, its chiral nature makes it useful in the production of enantiomerically pure compounds, which are important in pharmaceutical and agrochemical industries. Overall, 3-Piperidinemethanol, 1-methyl-, (3R)-(9CI) is an important compound with various applications in organic synthesis and pharmaceutical production.

InChI:InChI=1/C7H15NO/c1-8-4-2-3-7(5-8)6-9/h7,9H,2-6H2,1H3/t7-/m1/s1

Upstream product

• 205194-12-3 (R)-ethyl 1-methylpiperidine 3-carboxylate 
• 25137-01-3 (R)-ethyl nipecotate 
• 5166-67-6 ethyl 1-methylpiperidine-3-carboxylate 
• 116574-71-1 tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate 

Downstream Products

• 1159598-44-3 [(3R)-1-methylpiperidin-3-yl]methyl 4-(4-methylphenyl)piperazine-1-carboxylate 

Relevant articles and documents

AMINOESTER DERIVATIVES

The invention relates to novel compounds which are both phosphodiesterase 4 (PDE4) enzymeinhibitorsand muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase

Second site: In the crystal structure of human MALT1casp-Ig3 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) in complex with the tricyclic phenothiazine derivative thioridazine (violet in the picture), the inhibitor is bound in a hydrophobic pocket far from the active site. This explains the action of phenothiazine derivatives as noncompetitive, reversible inhibitors. Copyright

QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS

The invention relates to the use of compounds of the formula I: wherein ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which optionally may contain 1-3 heteroatoms selected independently from O, N and S; Z is -O-, -NH-, -S-, -CH2- or a direct bond; n is 0-5; m is 0-3; R represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C1-3alkyl, C1-3alkoxy, C1-3alkylsulphanyl, -NRR (wherein R and R, which may be the same or different, each represents hydrogen or C1-3alkyl), or RX- (wherein X and R are as defined herein; R represents hydrogen, oxo, halogeno, hydroxy, C1-4alkoxy, C1-4alkyl, C1-4alkoxymethyl, C1-4alkanoyl, C1-4haloalkyl, cyano, amino, C2-5alkenyl, C2-5alkynyl, C1-3alkanoyloxy, nitro, C1-4alkanoylamino, C1-4alkoxycarbonyl, C1-4alkylsulphanyl, C1-4alkylsulphinyl, C1-4alkylsulphonyl, carbamoyl, N-C1-4alkylcarbamoyl, N,N-di(C1-4alkyl)carbamoyl, aminosulphonyl, N-C1-4alkylaminosulphonyl, N,N-di(C1-4alkyl)aminosulphonyl, N-(C1-4alkylsulphonyl)amino, N-(C1-4alkylsulphonyl)-N-(C1-4alkyl)amino, N,N-di(C1-4alkylsulphonyl)amino, a C3-7alkylene chain joined to two ring C carbon atoms, C1-4alkanoylaminoC1-4alkyl, carboxy or a group RX (wherein X and R are as defined herein); and salts thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals, processes for the preparation of such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and compounds of formula I. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.