20520-50-7Relevant articles and documents
Iron-catalyzed imidative kinetic resolution of racemic sulfoxides
Wang, Jun,Frings, Marcus,Bolm, Carsten
supporting information, p. 966 - 969 (2014/02/14)
Kinetic resolution of racemic sulfoxides requires either custom substrates or shows moderate enantioselectivity, leading to achiral coproducts (such as sulfones) as an intrinsic part of the process. A new strategy is demonstrated that allows the resolution of racemic sulfoxides through catalytic asymmetric nitrene-transfer reactions. This approach gives rise to both optically active sulfoxides and highly enantioenriched sulfoximines. By using a chiral iron catalyst and a readily available iodinane reagent, high selectivity factors have been achieved under very practical reaction conditions. With respect to the substrate scope, it is noteworthy that this unprecedented imidative kinetic resolution of racemic sulfoxides provides access to both aryl-alkyl and dialkyl sulfoximines in highly enantioenriched forms. Copyright
Cu(I)-catalyzed sulfoximination
Mueller, Juergen F. K.,Vogt, Patrick
, p. 4805 - 4806 (2007/10/03)
The reaction of PhI=NTs with sulfoxides in the presence of catalytic amounts of CuOTf afforded the corresponding N-tosylsulfoximines in high yield. The use of enantiomerically pure sulfoxides allowed stereoselective access to N-tosylsulfoximines with comp
