205264-33-1

Basic information

• Product Name: Tert-Butyl4-(Isoquinolin-1-Yl)Piperazine-1-Carboxylate
• Synonyms: Tert-Butyl4-(Isoquinolin-1-Yl)Piperazine-1-Carboxylate;1-Boc-4-Isoquinolin-1-yl-piperazine
• CAS NO: 205264-33-1
• Molecular Formula: C₁₈H₂₃N₃O₂
• Molecular Weight: 313.39412
• Mol File: 205264-33-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Tert-Butyl4-(Isoquinolin-1-Yl)Piperazine-1-Carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Tert-Butyl4-(Isoquinolin-1-Yl)Piperazine-1-Carboxylate(205264-33-1)
• EPA Substance Registry System: Tert-Butyl4-(Isoquinolin-1-Yl)Piperazine-1-Carboxylate(205264-33-1)

Safety Data

• Hazardous Substances Data: 205264-33-1(Hazardous Substances Data)

Usage

General Description

Tert-Butyl4-(Isoquinolin-1-Yl)Piperazine-1-Carboxylate is a complex organic chemical compound known for its utility in the field of pharmaceutical research and development. It belongs to the chemical class of compounds referred to as piperazines - these contain a piperazine ring system, which is a saturated aliphatic six-member ring with two nitrogen atoms at opposite positions. Isoquinoline structural unit involved in its composition suggests potential pharmacological properties. The specific characteristics, including molecular structure, reactivity, physical and chemical properties of this compound may vary depending on its specific configuration and conditions. However, detailed information about its applications, toxicity, or safety measures are not readily available and may require further studies to fully comprehend.

Upstream product

• 634198-17-7 4-(3-chloro-1-isoquinolyl)-1-piperazinecarboxylic acid tert-butyl ester 
• 7742-73-6 1,3-dichloroisoquinoline 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 19493-44-8 1-chloroisoquinoline 
• 119-65-3 isoquinoline 
• 77278-40-1 tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate 
• 1532-71-4 1-bromoisoquinoline 

Downstream Products

• 126653-00-7 1-(1-piperazinyl)-isoquinoline 

Relevant articles and documents

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

C-N cross-coupling is one of the most valuable and widespread transformations in organic synthesis. Largely dominated by Pd- and Cu-based catalytic systems, it has proven to be a staple transformation for those in both academia and industry. The current study presents the development and mechanistic understanding of an electrochemically driven, Ni-catalyzed method for achieving this reaction of high strategic importance. Through a series of electrochemical, computational, kinetic, and empirical experiments, the key mechanistic features of this reaction have been unraveled, leading to a second generation set of conditions that is applicable to a broad range of aryl halides and amine nucleophiles including complex examples on oligopeptides, medicinally relevant heterocycles, natural products, and sugars. Full disclosure of the current limitations and procedures for both batch and flow scale-ups (100 g) are also described.

Site-Selective Copper-Catalyzed Amination and Azidation of Arenes and Heteroarenes via Deprotonative Zincation

Arene amination is achieved by site-selective C-H zincation followed by copper-catalyzed coupling with O-benzoylhydroxylamines under mild conditions. Key to this success is ortho-zincation mediated by lithium amidodiethylzincate base that is effective for a wide range of arenes, including nonactivated arenes bearing simple functionalities such as fluoride, chloride, ester, amide, ether, nitrile, and trifluoromethyl groups as well as heteroarenes including indole, thiophene, pyridine, and isoquinoline. An analogous C-H azidation is also accomplished using azidoiodinane for direct introduction of a useful azide group onto a broad scope of arenes and heteroarenes. These new transformations offer rapid access to valuable and diverse chemical space of aminoarenes. Their broad applications in organic synthesis and drug discovery are demonstrated in the synthesis of novel analogues of natural product (-)-nicotine and antidepressant sertraline by late-stage amination and azidation reactions.

ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise (I) wherein: Ra, R1, R2 and R3 are each, independently, hydrogen, or a substituent selected from halogen, CF3, alkyl, alkoxy, MeSO2, amino or aminocarbonyl (each optionally substituted by one or two groups selected from alkyl and benzyl) carboxy, or alkoxycarbonyl; or two adjacent of Ra and R1-4 together can form a 5-7 membered carbocyclic or heterocyclic ring which is optionally substituted by a substituent defined above; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, arylalkyl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, alkoxy or benzyloxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is CH or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.