205442-92-8

Basic information

• Product Name: (2S)-2-(2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolyl-2-phenylethan-1-ol
• Synonyms: (2S)-2-(2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolyl-2-phenylethan-1-ol
• CAS NO: 205442-92-8
• Molecular Weight: 219.327
• Mol File: 205442-92-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S)-2-(2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolyl-2-phenylethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolyl-2-phenylethan-1-ol(205442-92-8)
• EPA Substance Registry System: (2S)-2-(2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolyl-2-phenylethan-1-ol(205442-92-8)

Safety Data

• Hazardous Substances Data: 205442-92-8(Hazardous Substances Data)

Upstream product

• 75-16-1 methylmagnesium bromide 
• 205442-89-3 (3S,5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl<2,1-b>oxazolopyrrolidine 

Downstream Products

• 4209-65-8 (2R,5S)-2,5-dimethyltetrahydro-1H-1-pyrrolylidium chloride 

Relevant articles and documents

SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS

Disclosed are compounds of formula (I) which are bradykinin B1 receptor (B1R) antagonists. These compounds are useful to treat diseases or relieve adverse symptoms associated with inflammation and pain. The invention encompasses novel compounds and acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases involving inflammation and pain.

A short asymmetric synthesis of 2,5-disubstituted pyrrolidines

A novel approach to chiral 2,5-disubstituted pyrrolidines, starting from chiral 2-phenyl-glycimol, 1,5-dimethoxytetrahydrofuran, and benzotriazole, involves the diastereoselective substitution by Grignard reagents of a benzotriazolyl group in a crystalline intermediate obtained in high yield.