205442-95-1Relevant articles and documents
Pyrrolidine analogues of lobelane: Relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2)
Vartak, Ashish P.,Nickell, Justin R.,Chagkutip, Jaturaporn,Dwoskin, Linda P.,Crooks, Peter A.
experimental part, p. 7878 - 7882 (2010/08/06)
Ring size reduction of the central piperidine ring of lobelane yielded pyrrolidine analogues that showed marked inconsistencies in their ability to bind to the dihydrotetrabenazine (DTBZ) binding site on the vesicular monoamine transporter-2 (VMAT2) and t
A short asymmetric synthesis of 2,5-disubstituted pyrrolidines
Katritzky, Alan R.,Cui, Xi-Lin,Yang, Baozhen,Steel, Peter J.
, p. 1697 - 1700 (2007/10/03)
A novel approach to chiral 2,5-disubstituted pyrrolidines, starting from chiral 2-phenyl-glycimol, 1,5-dimethoxytetrahydrofuran, and benzotriazole, involves the diastereoselective substitution by Grignard reagents of a benzotriazolyl group in a crystalline intermediate obtained in high yield.