205692-60-0Relevant articles and documents
Light-responsive polymersomes with a charge-switch for targeted drug delivery
Bao, Chunyan,Chen, Rongrong,Fan, Jinyan,Lin, Qiuning,Wang, Chenxi,Yang, Huiting,Zhou, Yaowu,Zhu, Linyong
, p. 727 - 735 (2020)
Unlike the traditional block amphiphilic polymersomes, we herein report a lipid-like amphiphilic polymer that self-Assembles into photo-responsive polymersomes for drug delivery. The introduction of a quaternary ammonium moiety not only provides a hydrophilic segment of the polymersomes, but also enables electrostatic adsorption with folic acid, thus achieving the targeting of cancer cells with overexpression of folate receptor. Upon light irradiation, the photocleavage reaction of the o-nitrobenzyl moiety disintegrates polymersomes by changing the polymer structure from cationic amphiphilic state to zwitterionic hydrophilic state, thus realizing photo-Triggered drug release. The data showed that anticancer drugs (doxorubicin hydrochloride, DOX·HCl) can be loaded into the hydrophilic cavity of polymersomes and controllably released by photo-induced disintegration of polymersomes. Cellular assay showed that the active targeting of folic acid and photo-Triggered release endowed the DOX-loaded polymersomes with a higher cytotoxicity to HeLa cells. Such cationic polymersomes provide a novel strategy for designing effective and intelligent drug carriers, and have potential application as a novel integrated platform for targeted drug delivery.
Fluorescent columnar bis(boron difluoride) complexes derived from tetraketonates
Chen, Ya-Wen,Lin, Yen-Chun,Kuo, Hsiu-Ming,Lai, Chung K.
, p. 5465 - 5477 (2017/07/10)
Three new series of bis-(boron difluoride) complexes 1a-c derived from substituted tetraketonates 2a-c are reported, and their mesomorphic and optical properties have been investigated. Two single crystals of mesogenic ligand 2a (n = 6) and nonmesogenic d
H-Bonded metallomesogens: preparation, characterization, and mesomorphic studies of (3-hydroxypropylimino)propan-1,2-diols
Chien, Chieh,Chen, Chun-Jung,Sheu, Hwo-Shuenn,Lee, Gene-Hsiang,Lai, Chung K.
scheme or table, p. 3583 - 3592 (2010/06/21)
Two series of new Schiff bases 2 (n=8, 12, 16) derived from (3-hydroxypropyl imino)propan-1, 2-diol with a hydroxyl group at C19/C20-position and their palladium complexes 1 were prepared and their mesomorphic properties investigated