20579-43-5

Basic information

• Product Name: 3,4,5-trimethylpyridine
• Synonyms: 3,4,5-trimethylpyridine;Einecs 243-893-4
• CAS NO: 20579-43-5
• Molecular Formula: C₈H₁₁N
• Molecular Weight: 121.17964
• EINECS: 243-893-4
• Mol File: 20579-43-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 32.6-35.6 °C
• Boiling Point: 211.6°Cat760mmHg
• Flash Point: 71.2°C
• Appearance: /
• Density: 0.921g/cm³
• Vapor Pressure: 0.262mmHg at 25°C
• Refractive Index: 1.502
• PKA: 6.47±0.28(Predicted)
• CAS DataBase Reference: 3,4,5-trimethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-trimethylpyridine(20579-43-5)
• EPA Substance Registry System: 3,4,5-trimethylpyridine(20579-43-5)

Safety Data

• Hazardous Substances Data: 20579-43-5(Hazardous Substances Data)

Usage

Physical Form

Powder

Uses

3,4,5-trimethylpyridine is a useful research chemical.

InChI:InChI=1/C8H11N/c1-6-4-9-5-7(2)8(6)3/h4-5H,1-3H3

Upstream product

• 98490-98-3 2,6-dichloro-3,4,5-trimethyl-pyridine 
• 102471-57-8 1-benzyl-3,4,5-trimethyl-piperidin-4-ol 
• 3430-23-7 3,5-dibromo-4-methyl-pyridine 
• 594-27-4 tetramethylstannane 
• 625-92-3 3,5-dibromopyridine 
• 836-21-5 1-Benzyl-3,5-dimethyl-piperidin-4-one 
• 42324-07-2 2,4-dimethyl-3-oxo-pentanedioic acid diethyl ester 
• 110331-19-6 1-benzyl-3,5-dimethyl-4-oxo-piperidine-3,5-dicarboxylic acid diethyl ester 
• 98593-42-1 trimethyl-pyridine-2,6-diol 
• 497-03-0 2-methylbut-2-enal 
• 2450-71-7 Propargylamine 

Downstream Products

• 524775-16-4 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3,5-dimethyl-pyridine 

Relevant articles and documents

Studies on the coal tar bases. VI. Synthesis of 3,4,5-collidine.

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A simple, tandem approach to the construction of pyridine derivatives under metal-free conditions: A one-step synthesis of the monoterpene natural product, (-)-actinidine

A simple and modular one-step synthesis of diversely substituted pyridines from readily available α,β-unsaturated carbonyl compounds and propargylic amines has been developed. The present protocol has a broad substrate scope and allows access to multi-substituted pyridines with select control of the substitution pattern under mild and metal-free conditions. The reaction involves imine formation followed by concomitant cyclization through an allenyl intermediate to afford pyridines in excellent yields, with water as the sole by-product. This mild strategy is also suitable for functionalization of natural products or other advanced intermediates having α,β-unsaturated carbonyl functionality. The utility of the present protocol was showcased with the synthesis of the monoterpene alkaloid, (-)-actinidine, an ant-associated iridoid.

Substituted 4-(2,2-Diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters

A detailed SAR study directed toward the optimization of pharmacokinetic parameters for analogues of L-791,943 is reported. The introduction of a soft metabolic site on this structure permitted the identification of L-826,141 as a potent phosphodiesterase type 4 (PDE4) inhibitor that is well absorbed and that presents a shorter half-life than L-791,943 in a variety of animal species. The efficacy of L-826,141 is also demonstrated in different in vivo models.