205885-39-8Relevant articles and documents
Copper-Catalyzed Synthesis of Terminal vs. Fluorine-Substituted N-Allenamides via Addition of Diazo Compounds to Terminal Ynamides
Zheng, Yongxiang,Moegle, Baptiste,Ghosh, Santanu,Perfetto, Anna,Luise, Davide,Ciofini, Ilaria,Miesch, Laurence
, (2021/12/14)
A copper-mediated coupling reaction between ynamides and diazo-compounds to produce N-allenamides is reported for the first time. This method enables facile and rapid access to terminal N-allenamides by using commercially available TMS-diazomethane with w
Metal-Free Hydrophosphoryloxylation of Ynamides: Rapid Access to Enol Phosphates
An, Dalie,Zhang, Weinan,Pan, Bin,Zhao, Yingying
supporting information, p. 314 - 317 (2020/12/11)
We herein report a metal-free hydrophosphoryloxylation of ynamides with phosphoric acids, which provides an expeditious route to access useful enol phosphates. The advantages of this protocol include exclusive selectivity, short reaction time, high efficiency, and broad substrate scope. Additionally, the products can serve as good partners in Suzuki-Miyaura cross-coupling.
Direct Synthesis of CF2H-Substituted 2-Amidofurans via Copper-Catalyzed Addition of Difluorinated Diazoacetone to Ynamides
Zheng, Yongxiang,Perfetto, Anna,Luise, Davide,Ciofini, Ilaria,Miesch, Laurence
, p. 5528 - 5532 (2021/07/26)
The significance of molecules containing difluoromethyl groups is driven by their potential applications in pharmaceutical and agrochemical science. Methods for the incorporation of lightly fluorinated groups such as CF2H have been less well developed. He