20594-85-8

Basic information

• Product Name: 6,7-de-O-methylene-α-peltatin
• Synonyms: 6,7-de-O-methylene-α-peltatin
• CAS NO: 20594-85-8
• Molecular Weight: 388.374
• Mol File: 20594-85-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6,7-de-O-methylene-α-peltatin(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-de-O-methylene-α-peltatin(20594-85-8)
• EPA Substance Registry System: 6,7-de-O-methylene-α-peltatin(20594-85-8)

Safety Data

• Hazardous Substances Data: 20594-85-8(Hazardous Substances Data)

Upstream product

• 568-53-6 (5R,5aR,8aR)-10-Hydroxy-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 

Relevant articles and documents

Antitumor Agents. 78. Inhibition of Human DNA Topoisomerase II by Podophyllotoxin and α-Peltatin Analogues

It has been reported that the action of etoposide (VP-16) (14) as an antitumor agent is mediated through its interaction with DNA topoisomerase II which results in DNA breakage inside the cell.In order to understand the mechanism of action as well as structure-activity relationships of 14, several novel, synthetic and some naturally occurring analogues related to podophyllotoxin were examined for inhibition of the DNA topoisomerase II activity.Compound 2 exhibited enhanced activity and compound 5 slightly diminished activity relative to 14.A 4β-substituted ether at the C ring and O-demethylation at the E ring appear to enhance activity.