205999-74-2

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-(3-hydroxyphenyl)-3,4-dimethyl-, 1,1-dimethylethyl ester, (3R,4R)-
• CAS NO: 205999-74-2
• Molecular Formula: C18H27NO3
• Molecular Weight: 305.417
• Mol File: 205999-74-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-(3-hydroxyphenyl)-3,4-dimethyl-, 1,1-dimethylethyl ester, (3R,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-(3-hydroxyphenyl)-3,4-dimethyl-, 1,1-dimethylethyl ester, (3R,4R)-(205999-74-2)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-(3-hydroxyphenyl)-3,4-dimethyl-, 1,1-dimethylethyl ester, (3R,4R)-(205999-74-2)

Safety Data

• Hazardous Substances Data: 205999-74-2(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 119193-19-0 3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol 

Downstream Products

• 205999-77-5 3-[(3R,4R)-4-(3-Benzyloxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-1-phenyl-cyclohexanol 
• 205999-81-1 (+)-(3R,4R)-4-(3-(benzyloxy)phenyl)-3,4-dimethylpiperidine 
• 918829-72-8 tert-butyl (2R,4R,5R)-2-(benzyl(3-ethoxy-3-oxopropyl)carbamoyl)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-78-4 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-2-cyclohexyl-1-methoxy-1-oxoethyl-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-77-3 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((R)-1-methoxy-1-oxo-3-phenylpropan-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-76-2 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-1-methoxy-1-oxo-3-phenylpropan-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-68-2 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((R)-2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-64-8 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-79-5 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-1-methoxy-3-methyl-1-oxobutan-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-67-1 3-((3S,7R,8R,9aR)-2-benzyl-7,8-dimethyl-3-phenyl-octahydro-1H-pyrido[1,2-a]pyrazin-8-yl)phenyl trifluoromethanesulfonate 
• 918829-75-1 tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-(2-methoxy-2-oxo-1-phenylethylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate 
• 918829-82-0 methyl 2-(S)-cyclohexyl-2-((2R,4R,5R)-4-(3-hydroxyphenyl)-4,5-dimethylpiperidine-2-carboxamido)-acetate 
• 918829-92-2 (7R,8R,9aR)-8-(3-(benzyloxy)phenyl)-7,8-dimethyl-2-(phenylsulfonyl)-octahydro-1H-pyrido[1,2-a]pyrazine 
• 918829-08-0 3-(2-benzyl-7,8-dimethyl-3-phenyl-octahydro-pyrido[1,2-a]pyrazin-8-yl)-benzoic acid methyl ester 

Relevant articles and documents

NOVEL OPIOID ANTAGONISTS

Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.

trans-3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines: A novel class of μ-Selective opioid antagonists

trans-3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines constitute a novel class of μ opioid receptor antagonists. The CONH2 group was found to be an effective isostere of the phenolic OH moiety. Structure-activity relationships at the piperidine