206184-49-8 Usage
Description
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate, also known as Tenofovir Monohydrate, is a pharmaceutical compound with potent antiviral and anti-neoplastic properties. It is a nucleotide analog reverse transcriptase inhibitor, specifically designed to target and inhibit the replication of certain viruses, including HIV-1. The monohydrate form of Tenofovir is a white powder solid, which is widely used in the pharmaceutical industry for the treatment of HIV infection and as a secondary standard for quality control in pharmaceutical laboratories and manufacturing.
Uses
Used in Antiviral Applications:
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate is used as an antiretroviral agent for the treatment of HIV-1 infection. It works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of the virus, thus suppressing the viral load and preventing the progression of the disease.
Used in Anticancer Applications:
In the field of oncology, 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate is used as an antineoplastic agent and a thymidylate synthase inhibitor. It interferes with the synthesis of DNA and RNA in cancer cells, thereby inhibiting their growth and proliferation.
Used in Pharmaceutical Quality Control:
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate is used as a secondary standard in pharmaceutical quality control. It provides a convenient and cost-effective alternative to the preparation of in-house working standards, ensuring the accuracy and reliability of drug testing and analysis.
Used in Drug Development and Research:
In the pharmaceutical industry, 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate is used as a key compound in the development of new antiviral and anticancer drugs. Its unique properties and mechanisms of action make it a valuable tool for researchers in the discovery and optimization of novel therapeutic agents.
Used in Drug Delivery Systems:
To enhance the bioavailability and therapeutic outcomes of 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate, various drug delivery systems have been developed. These systems, which may include organic and metallic nanoparticles, aim to improve the compound's delivery to target cells, ensuring more effective treatment of HIV-1 infection and cancer.
Biological Activity
tenofovir hydrate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(hiv-1) and hepatitis b [1].tenofovir hydrate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. in addition, tenofovir hydrate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of hiv-1infection with ec50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. and the ec90 values of tenofovir hydrate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1].
Check Digit Verification of cas no
The CAS Registry Mumber 206184-49-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,6,1,8 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 206184-49:
(8*2)+(7*0)+(6*6)+(5*1)+(4*8)+(3*4)+(2*4)+(1*9)=118
118 % 10 = 8
So 206184-49-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H14N5O4P.H2O/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14;/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17);1H2/t6-;/m1./s1
