206201-64-1Relevant articles and documents
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
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Page/Page column 169-170, (2021/12/31)
The present invention relates to isoxazolidines of formula I and their use as receptor-interacting protein kinase 1 inhibitors, for example in the treatment of diseases and disorders mediated by RIP kinase (1) such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease (IBD), Crohn's disease or ulcerative colitis.
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues
Patrick, Donald A.,Bakunov, Stanislav A.,Bakunova, Svetlana M.,Wenzler, Tanja,Brun, Reto,Tidwell, Richard R.
, p. 559 - 576 (2014/01/17)
Fifty novel prodrugs and aza-analogues of 3,5-bis(4-amidinophenyl)isoxazole and its derivatives were prepared. Eighteen of the 24 aza-analogues exhibited IC50 values below 25 nM against Trypanosoma brucei rhodesiense or Plasmodium falciparum. S
SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS
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Page/Page column 147, (2009/03/07)
Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.