206258-02-8

Basic information

• Product Name: 4-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-8-trifluoromethyl-quinoline-3-carboxylic acid
• Synonyms: 4-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-8-trifluoromethyl-quinoline-3-carboxylic acid
• CAS NO: 206258-02-8
• Molecular Weight: 516.497
• Mol File: 206258-02-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-8-trifluoromethyl-quinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-8-trifluoromethyl-quinoline-3-carboxylic acid(206258-02-8)
• EPA Substance Registry System: 4-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-8-trifluoromethyl-quinoline-3-carboxylic acid(206258-02-8)

Safety Data

• Hazardous Substances Data: 206258-02-8(Hazardous Substances Data)

Upstream product

• 23851-84-5 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 119059-70-0 N-benzyl-4-methoxybenzenesulfonamide 
• 31602-11-6 ethyl 4-chloro-8-(trifluoromethyl)quinoline-3-carboxylate 
• 206257-97-8 4-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors

Compounds of the formula which are useful in disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

ACETYLENIC ORTHO-SULFONAMIDO AND PHOSPHINIC ACID AMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS TACE INHIBITORS

Compounds of the formula are provided wherein P and Q are provided that when P is Q is and vice versa; which are useful in disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors

This invention provides, low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF-α converting enzyme (TACE, tumor necrosis factor-α converting enzyme) of formula: B wherein B is P and Q are provided that when P is Q is and vice versa; or a pharmaceutically acceptable salt thereof.