206360-56-7

Basic information

• Product Name: 2,2-DIFLUORO-2-(4-NITROPHENYL)ACETIC ACID
• Synonyms: 2,2-DIFLUORO-2-(4-NITROPHENYL)ACETIC ACID
• CAS NO: 206360-56-7
• Molecular Formula: C₈H₅F₂NO₄
• Molecular Weight: 217.13
• Mol File: 206360-56-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-DIFLUORO-2-(4-NITROPHENYL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUORO-2-(4-NITROPHENYL)ACETIC ACID(206360-56-7)
• EPA Substance Registry System: 2,2-DIFLUORO-2-(4-NITROPHENYL)ACETIC ACID(206360-56-7)

Safety Data

• Hazardous Substances Data: 206360-56-7(Hazardous Substances Data)

Usage

General Description

2,2-difluoro-2-(4-nitrophenyl)acetic acid is a chemical compound with the molecular formula C8H6F2NO4. It is a derivative of acetic acid, containing two fluorine atoms and a nitrophenyl group. 2,2-difluoro-2-(4-nitrophenyl)acetic acid is often used in the synthesis of pharmaceutical drugs and agrochemicals due to its potential biological activity. Its unique structure and properties make it a valuable building block in organic chemistry for the creation of various functional groups and pharmacologically active compounds. Additionally, its specific chemical properties make it a useful tool for chemical research and drug development.

Upstream product

• 206360-55-6 2,2-difluoro-2-(4'-nitrophenyl)acetamide 
• 73805-25-1 dichloro-(4-nitro-phenyl)-acetonitrile 
• 555-21-5 4-Nitrophenylacetonitrile 
• 636-98-6 p-nitrobenzene iodide 
• 243656-25-9 2,2-difluoro-2-(4-nitrophenyl)acetic acid ethyl ester 
• 667-27-6 Ethyl bromodifluoroacetate 

Downstream Products

• 206360-57-8 2,2-difluoro-2-(4'-nitrophenyl)acetyl chloride 
• 29848-57-5 4-(difluoromethyl)nitrobenzene 
• 403-50-9 p-nitrobenzoyl fluoride 

Relevant articles and documents

Silver-catalyzed decarboxylative radical allylation of α,α-difluoroarylacetic acids for the construction of CF2-allyl bonds

An efficient silver-catalyzed method of decarboxylative radical allylation of α,α-difluoroarylacetic acids to build CF2-allyl bonds has been developed. Using allylsulfone as an allyl donor, α,α-difluorine substituted arylacetic acids bearing various functional groups are successfully allylated to access a series of 3-(α,α-difluorobenzyl)-1-propylene compounds in moderate to excellent yields in aqueous CH3CN solution under the mild conditions. Experimental studies disclosed that the α-fluorine substitution of arylacetic acid has a great influence on free radical activity and reactivity.

Controlling the cleavage of carbon-carbon bonds to generate α,α-difluorobenzyl carbanions for the construction of difluoromethylbenzenes

Controlling the cleavage of carbon-carbon bonds during a chemical reaction is a substantial challenge; however, synthetic methods that accomplish this objective produce valuable and often unexplored reactivity. We have designed a mild process to generate α,α-difluorobenzyl carbanions in the presence of potassium carbonate by exploiting the cleavage of C-C bonds during the release of trifluoroacetate. The initiating reagent is potassium carbonate, which represents an improvement over existing protocols that require a strong base. Fragmentation studies across substituted arenes and heteroarenes were conducted along with computational analyses to elucidate reactivity trends. Furthermore, the mildly generated α,α-difluorobenzyl carbanions from electron-deficient aromatics and heteroaromatic rings can react with aldehydes to create derivatives of difluoromethylbenzenes, which are valuable synthetic targets.

Method of manufacturing arom. defluoromethyl compd.

PROBLEM TO BE SOLVED: To provide a method for easily producing an aromatic compound having a difluoromethyl group in high yield while using a reagent having low toxicity. SOLUTION: The method for producing the aromatic difluoromethyl compound includes reacting an aromatic difluoroacetic acid in the presence of a metal halide (especially potassium fluoride). COPYRIGHT: (C)2011,JPOandINPIT