206559-48-0Relevant articles and documents
Heterocyclization of Aromatic Amino Acids: Novel Syntheses and Antibacterial Activity of Fused, Non-fused, and Spiro Polyheterocyclic Derivatives
Assy, M. G.,Galahom, M. M.,Hamed, E. O.
, p. 1062 - 1069 (2020)
Abstract: Commercially available p-aminobenzoic acidwas used as a precursor for the synthesis of novel fused, non-fused, and spiropolyheterocyclic derivatives bearing indene, imidazole, pyrazole, and/ortriazine nucleus via addition to simple and accessibl
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics
Duffy, Kevin J.,Shaw, Anthony N.,Delorme, Evelyne,Dillon, Susan B.,Erickson-Miller, Connie,Giampa, Leslie,Huang, Yifang,Keenan, Richard M.,Lamb, Peter,Liu, Nannan,Miller, Stephen G.,Price, Alan T.,Rosen, Jon,Smith, Heather,Wiggall, Kenneth J.,Zhang, Lihua,Luengo, Juan I.
, p. 3573 - 3575 (2007/10/03)
High-throughput screening has resulted in the discovery of thiosemicarbazone thrombopoietin mimics. A shared pharmacophore hypothesis between this series and a previously identified class, the pyrazol-4-ylidenehydrazines, led to the rapid optimization of
