20660-73-5

Basic information

• Product Name: 2-(Bromomethyl)-3-nitropyridine
• Synonyms: 2-(Bromomethyl)-3-nitropyridine
• CAS NO: 20660-73-5
• Molecular Formula: C₆H₅BrN₂O₂
• Molecular Weight: 217.0201
• Mol File: 20660-73-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-(Bromomethyl)-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Bromomethyl)-3-nitropyridine(20660-73-5)
• EPA Substance Registry System: 2-(Bromomethyl)-3-nitropyridine(20660-73-5)

Safety Data

• Hazardous Substances Data: 20660-73-5(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)-3-nitropyridine is a chemical compound that consists of a pyridine ring with a bromomethyl group and a nitro group attached to it. It is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-(Bromomethyl)-3-nitropyridine is known for its reactivity and is frequently used in organic synthesis to introduce the bromomethyl and nitro functional groups into other molecules. It is important to handle this compound with caution, as it is considered to be a hazardous material and should be stored and used in a well-ventilated area with proper safety equipment.

Upstream product

• 18699-87-1 2-methyl-3-nitropyridine 

Downstream Products

• 192182-72-2 2-(2-methylphenoxymethyl)-3-nitropyridine 
• 1310472-14-0 (4-fluorophenyl)-(3-nitropyridin-2-ylmethyl)-amine 

Relevant articles and documents

Design, synthesis, and pharmacological evaluation of fused β-homophenylalanine derivatives as potent DPP-4 inhibitors

Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatment of type 2 diabetes. Herein, a series of fused β-homophenylalanine derivatives as novel DPP-4 inhibitors were designed, synthesized, and evaluated for their inhibitory activities against DPP-4. Most of them displayed excellent DPP-4 inhibitory activities and good selectivity. Among them, 9aa, 18a, and 18m also showed good efficacy in an oral glucose tolerance test (OGTT) in ICR mice. Moreover, when dosed 8 h prior to glucose challenge, 18m showed significantly greater potency than sitagliptin. It thus provides potential candidates for the further development into potent drugs targeting DPP-4.

PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The present invention provides novel pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

Pyridylcarbamates, process and intermediates for their preparation, and their use

A pyridylcarbamate compound of the formula I STR1 wherein R' is hydrogen; opt. subst. alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkylcarbonyl and alkoxycarbonyl; R" is opt. subst. alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl; or is hydrogen when V is nitrogen; V is O, S or N; X is cyano; nitro; halogen; opt. subst. alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, or an opt. subst. bridge which is bonded to two adjacent C atoms of the pyridyl ring; n is 0, 1, 2 or 3; R is halogen; OH; SH; NH; CHO; CO2 H; CONH2 ; opt. subst. alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or hetaryl, each being bonded directly or via O, S, N, CO2 or CONH; or together with X and the pyridyl ring to which they are bonded an opt. subst. bicyclus, its manufacture, and pesticidal and fungicidal compositions containing I.