206759-97-9

Basic information

• Product Name: 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate
• Synonyms: 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate
• CAS NO: 206759-97-9
• Molecular Weight: 409.482
• Mol File: 206759-97-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 582.5±50.0 °C(Predicted)
• Density: 1.176±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate(206759-97-9)
• EPA Substance Registry System: 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate(206759-97-9)

Safety Data

• Hazardous Substances Data: 206759-97-9(Hazardous Substances Data)

Upstream product

• 71989-18-9 Fmoc-Glu(OtBu)-OH 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 153815-59-9 4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-pentanoic acid tert-butyl ester 
• 222639-57-8 γ-tert-butyl α-S-ethyl (S)-N-(fluorenylmethoxycarbonyl)thioglutamate 
• 160002-62-0 (S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester 

Downstream Products

• 1383854-82-7 C₄₆H₇₀N₈O₈ 
• 1383854-84-9 C₇₂H₁₁₁N₁₃O₁₂ 
• 1287745-42-9 C₃₃H₃₈N₂O₆ 
• 1287745-87-2 C₃₅H₄₀N₂O₇ 
• 1287745-60-1 C₄₂H₄₆N₂O₇ 

Relevant articles and documents

PNA probe

Disclosed herein are improved PNA based monomers, nucleobases, oligomers and probes for use in a variety of different methods of analysing nucleic acids. Further, the disclosure provides methods of preparing the modified and improved PNA molecules as well as methods of using the same.

Β?CATENIN/ B-CELL LYMPHOMA 9 PROTEIN?PROTEIN INTERACTION INHIBITING PEPTIDOMIMETICS

Disclosed herein is a series of helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). As disclosed herein, sulfono-γ-AApeptides can structurally and functionally mimic the α-helical domain of BCL9, and selectively disrupt β?catenin/BCL9 PPIs with even higher potency. More intriguingly, these sulfono-γ-AApeptides can enter cancer cells, bind with β?catenin and disrupt β?catenin/BCL PPI, and exhibit excellent cellular activity, which is much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies demonstrated the remarkable stability of the helical sulfono-γ-AApeptides, with no degradation in the presence of pronase for 24 h, augmenting their biological potential.

Comparison of backbone modification in protein β-sheets by α→γ residue replacement and α-residue methylation

The mimicry of protein tertiary structure by oligomers with unnatural backbones is a significant contemporary research challenge. Among common elements of secondary structure found in natural proteins, sheets have proven the most difficult to address. Here, we report the systematic comparison of different strategies for peptide backbone modification in β-sheets with the goal of identifying the best method for replacing a multi-stranded sheet in a protein tertiary fold. The most effective sheet modifications examined led to native-like tertiary folding behavior with a thermodynamic folded stability comparable to the prototype protein on which the modified backbones are based. This journal is the Partner Organisations 2014.