20685-09-0Relevant articles and documents
ap-9-(o-Methylphenyl)-9-fluorenol, a structure exhibiting several aryl-H...π(arene) intermolecular interactions
Meyers, Cal Y.,Robinson, Paul D.,McLean, Aaron W.
, p. o712-o714 (2003)
The intermolecular interactions exhibited by C20H16O (I) were analyzed. The intermolecular interactions resulted in planar molecular arrays in which each molecule interacted with six adjacent molecules. No O-H·O-H or oh·π interactions were found within hydrogen-bonding distances. Crystalline (I) melted sharply without molecular decomposition (NMR), but the cooled melt recrystallized after a certain period of time. The melting point of the reformed crystals was identical to the original crystals.
The p: K a values of N-aryl imidazolinium salts, their higher homologues, and formamidinium salts in dimethyl sulfoxide
Cole, Marcus L.,Dunn, Michelle H.,Harper, Jason B.,Konstandaras, Nicholas,Luis, Ena T.
supporting information, p. 1910 - 1917 (2020/03/23)
A series of imidazolinium salts, their six-, seven- A nd eight-membered homologues, and the related formamidinium salts were prepared, and their pKa values were determined in DMSO at 25 °C using the bracketing indicator method. The effect of each type of structural variation on the acidity of each salt was considered, particularly noting the importance of ring size and the effect of the steric and electronic nature of the N-aryl substituents. The effect of a cyclic structure was also probed through comparing the cyclic systems with the corresponding formamidinium salts, noting the importance of conformational flexibility in the latter cases. Along with allowing choice of appropriate bases for deprotonation of these species, it is anticipated that the data presented will aid in the understanding of the nucleophilicity, and potentially catalytic efficacy, of the corresponding carbenes.
Tricylic amino-acid derivatives
-
, (2008/06/13)
Described herein are compounds which have the general formula: or a prodrug or pharmaceutically acceptable salt, solvate or hydrate thereof wherein: R1 is selected from the group consisting of H, alkyl and the counter ion for a basic addition salt; X is selected from the group consisting of CR9R10, S, O, SO, SO2, NH and N-alkyl; R2, R3, R4, R9 and R10 are independently selected from the group consisting of H and alkyl; R5 and R6 are independently selected from the group consisting of H, alkyl and phenyl, or, alternatively, R5 and R6 together may form a methylene group or a 3- to 6-membered a spirocyclic group; wherein, when X is CR9R10, one or both pairs of R5 and R9 or R6 and R10 may join to form a double or triple bond R7 is selected from the group consisting of Formula II-V: which are all optionally substituted, at nodes other than R8, with 1-4 substituents independently selected from the group consisting of alkyl, halo, aryl (which may be substituted as for R8), trifluoromethyl, trifluoromethoxy, nitro, cyano, amino, mono-alkylamino, di-alkylamino, alkoxycarbonyl, alkylcarbonyl, alkoxythiocarbonyl, alkylthiocarbonyl, alkoxy, alkylS-, phenoxy, -SO2NH2, -SO2NHalkyl, -SO2N(alkyl)2 and 1,2-methylenedioxy; and wherein any of the benzo-fused rings in structures II to V may be replaced by a 5- or 6-membered heterocyclic ring selected from the group consisting of pyridine, thiophene, furan and pyrrole; wherein R8 is selected from the group consisting of H, alkyl, benzyl, cycloalkyl, indanyl and an optionally substituted aryl group, wherein the optional substituents are independently selected from 1-4 members of the group consisting of alkyl, halo, aryl, trifluoromethyl, trifluoromethoxy, nitro, cyano, amino, mono-alkylamino, di-alkylamino, alkoxycarbonyl, alkylcarbonyl, alkoxythiocarbonyl, alkylthiocarbonyl, alkoxy, alkylS-, phenoxy, -SO2NH2, -SO2NHalkyl, -SO2N(alkyl)2 and 1,2-methylenedioxy; -represents a single or double bond; Y is selected from the group consisting of O, S, SO, NH, N-alkyl, CH2, CH-alkyl, C(alkyl)2, and C=O; Z is selected from the group consisting of CH2, O, S, NH and N-alkyl when-is a single bond; Z is selected from the group consisting of CH and N when-is a double bond. Also described is the use of these compounds as pharmaceuticals.
