206884-21-1

Basic information

• Product Name: N-(3-acetamido-2,6-dichlorobenzylidene)-4-aminoisoquinoline
• Synonyms: N-(3-acetamido-2,6-dichlorobenzylidene)-4-aminoisoquinoline
• CAS NO: 206884-21-1
• Molecular Weight: 358.227
• Mol File: 206884-21-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-acetamido-2,6-dichlorobenzylidene)-4-aminoisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-acetamido-2,6-dichlorobenzylidene)-4-aminoisoquinoline(206884-21-1)
• EPA Substance Registry System: N-(3-acetamido-2,6-dichlorobenzylidene)-4-aminoisoquinoline(206884-21-1)

Safety Data

• Hazardous Substances Data: 206884-21-1(Hazardous Substances Data)

Upstream product

• 206884-17-5 3-acetamido-2,6-dichlorobenzylalcohol 
• 167837-45-8 3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene 
• 1125-60-6 isoquinolin-5-ylamine 
• 206884-14-2 3-acetamido-2,6-dichlorobenzaldehyde 

Downstream Products

• 206882-95-3 N-(3-acetamido-2,6-dichlorobenzamido)-4-aminoisoquinoline 
• 206882-94-2 N-(3-acetamido-2,6-dichlorobenzamido)-4-aminoisoquinoline N-oxide 

Relevant articles and documents

Studies on anti-Helicobacter pylori agents. Part 1: Benzyloxyisoquinoline derivatives

The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives that was discovered by a random screening process, are described. In the in vitro assay, compound 10c containing a 3-acetamido-2,6-dichlorobenzyl substituent was found to have extremely potent activity against H. pylori and no activity against other common bacteria. The anti-H. pylori activity of 10c was superior to that of amoxicillin (AMPC) (1) and clarithromycin (CAM) (2). However, 10c did not show in vivo efficacy in a mouse infection model; a feature attributed to the lack of strong bactericidal activity at short contact times. (C) 1999 Elsevier Science Ltd.