207277-11-0

Basic information

• Product Name: 5-methyl-3-Thiophenemethanol
• Synonyms: 5-methyl-3-Thiophenemethanol
• CAS NO: 207277-11-0
• Molecular Formula: C6H8OS
• Molecular Weight: 128.19212
• Mol File: 207277-11-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-methyl-3-Thiophenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-3-Thiophenemethanol(207277-11-0)
• EPA Substance Registry System: 5-methyl-3-Thiophenemethanol(207277-11-0)

Safety Data

• Hazardous Substances Data: 207277-11-0(Hazardous Substances Data)

Upstream product

• 71637-34-8 3-hydroxymethyl-thiophene 
• 74-88-4 methyl iodide 
• 117657-52-0 tert-butyl(dimethyl)(3-thienylmethoxy)silane 
• 19156-50-4 5-methyl-thiophene-3-carboxylic acid 
• 29421-72-5 2-methyl-4-thiophenecarboxaldehyde 

Downstream Products

• 29421-72-5 2-methyl-4-thiophenecarboxaldehyde 

Relevant articles and documents

Polypyridyl iridium(III) based catalysts for highly chemoselective hydrogenation of aldehydes

Iridium-catalyzed transfer hydrogenation (TH) of carbonyl compounds using HCOOR (R = H, Na, NH4) as a hydrogen source is a pivotal process as it provides the clean process and is easy to execute. However, the existing highly efficient iridium catalysts work at a narrow pH; thus, does not apply to a wide variety of substrates. Therefore, the development of a new catalyst which works at a broad pH range is essential as it can gain a broader scope of utilization. Here we report highly efficient polypyridyl iridium(III) catalysts, [Ir(tpy)(L)Cl](PF6)2 {where tpy = 2,2′:6′,2′'-Terpyridine, L = phen (1,10-Phenanthroline), Me2phen (4,7-Dimethyl-1,10-phenanthroline), Me4phen (3,4,7,8-Tetramethyl-1,10-phenanthroline), Me2bpy (4,4′-Dimethyl-2–2′-dipyridyl)} for the chemoselective reduction of aldehydes to alcohols in aqueous ethanol and sodium formate as the hydride source. The reaction can be carried out efficiently in broad pH ranges, from pH 6 to 11. These catalysts are air stable, easy to prepare using commercially available starting materials, and are highly applicable for a wide range of substrates, such as electron-rich or deficient (hetero)arenes, halogens, phenols, alkoxy, ketones, esters, carboxylic acids, cyano, and nitro groups. Particularly, acid and hydroxy groups containing aldehydes were reduced successfully in basic and acidic reaction conditions, demonstrating the efficiency of the catalyst in a broad pH range with high conversion rates under microwave irradiation.

MACROCYCLES AS PDE1 INHIBITORS

The present invention provides macrocycles of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound which compound is useful in the treatment of a psychiatric disorder and their combined use as a medicament, in particular for the treatment of psychiatric and/or cognitive disorders.