20735-74-4Relevant articles and documents
Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases
Ulrich, Scott M,Sallee, Nathan A,Shokat, Kevan M
, p. 3223 - 3227 (2002)
This report describes the synthesis of N4-(benzyl) AICAR triphosphate, a conformationally restrained analogue of N4-(benzyl) ribavirin triphosphate. Both of these nucleotides were evaluated as phosphodonors for wild-type p38 MAP kina
Synthesis of 4-N-alkyl and ribose-modified AICAR analogues on solid support
Oliviero, Giorgia,Amato, Jussara,Borbone, Nicola,D'Errico, Stefano,Piccialli, Gennaro,Bucci, Enrico,Piccialli, Vincenzo,Mayol, Luciano
, p. 6475 - 6481 (2008/09/21)
Herein, we report the solid-phase synthesis of several 5-aminoimidazole-4-(N-alkyl)carboxamide-1-ribosides (4-N-alkyl AICARs) and the corresponding 2′,3′-secoriboside derivatives. The method uses the N-1-dinitrophenyl-inosine 5′-bonded to a solid support.
METHODS, COMPOSITIONS, AND FORMULATIONS FOR PREVENTING OR REDUCING ADVERSE EFFECTS IN A PATIENT
-
Page/Page column 79-80, (2010/11/24)
The present invention provides methods, compositions, formulations, and kits related to acadesine, or a prodrug, analog, or salt thereof, and/or a blood clotting inhibitor for preventing or reducing adverse side effects in a patient. The type of patient that may benefit includes a patient with decreased left ventricular function, a patient with a prior myocardial infarction, a patient undergoing non-vascular surgery, or a fetus during labor and delivery.
