207402-09-3Relevant articles and documents
Total synthesis of mycophenolic acid
Covarrubias-Zú?iga, Adrián,Gonzalez-Lucas, Armando,Domínguez, Mireya M.
, p. 1989 - 1994 (2007/10/03)
A convergent total synthesis of the natural compound mycophenolic acid 1 is described. The synthetic strategy for the construction of the hexasubstituted aromatic nucleus was based on a ring annulation sequence, involving a Michael addition reaction and intramolecular Dieckmann condensation reaction in situ as the key step. Subsequent transformations of the substituents afforded the target mycophenolic acid 1.