207515-11-5

Basic information

• Product Name: (C₁₆H₁₂ClN₂O)Au(P(C₆H₅)3)
• Synonyms: (C₁₆H₁₂ClN₂O)Au(P(C₆H₅)3)
• CAS NO: 207515-11-5
• Molecular Weight: 742.994
• Mol File: 207515-11-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (C₁₆H₁₂ClN₂O)Au(P(C₆H₅)3)(CAS DataBase Reference)
• NIST Chemistry Reference: (C₁₆H₁₂ClN₂O)Au(P(C₆H₅)3)(207515-11-5)
• EPA Substance Registry System: (C₁₆H₁₂ClN₂O)Au(P(C₆H₅)3)(207515-11-5)

Safety Data

• Hazardous Substances Data: 207515-11-5(Hazardous Substances Data)

Upstream product

• 14243-64-2 (triphenylphosphine)gold(I) chloride 
• 439-14-5 diazepam 

Downstream Products

• 24169-93-5 triphenylphosphinegold(III) tribromide 
• 207515-22-8 (C₁₉H₁₆ClN₂O)[Au(P(C₆H₅)3)]2⁽¹⁺⁾*BF₄^(1-)=[(C₁₉H₁₆ClN₂O)[Au(P(C₆H₅)3)]2]BF₄ 
• 207515-20-6 (C₁₆H₁₂ClN₂O)[Au(P(C₆H₅)3)]2⁽¹⁺⁾*BF₄^(1-)=[(C₁₆H₁₂ClN₂O)[Au(P(C₆H₅)3)]2]BF₄ 
• 207515-15-9 (C₁₉H₁₆ClN₂O)Au(P(C₆H₅)3) 
• 79384-10-4 bromo(triphenylphosphine)gold(I) 
• 14243-64-2 (triphenylphosphine)gold(I) chloride 

Relevant articles and documents

C(3) aurated 1,4-benzodiazepin-2-ones. Synthesis and characterization. Crystal structure of (L)Au[P(C6H4CH3-4)3] (HL=7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, DIAZEPAM)

The synthesis of a series of gold(I) metallated derivatives of some 1,4-benzodiazepin-2-ones is described. They include mononuclear (L)Au(PR3) (R=C6H5, C6H4CH3-4 or C2H5) as well as dinuclear species (L)Au(Ph2P(CH2)nPPh2)Au(L), n=2, 3 (HL=7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, DIAZEPAM or 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one, PRAZEPAM). The deprotonated ligand is bonded to the AuPR3 moiety through the C(3) atom. Activation of the C(sp3)-H bond is achieved by means of a strong base in the presence of the phosphinegold chloride intermediate. The structure of (L)Au[P(C6H5CH3-4)3] has been determined by X-ray diffraction. Some aspects of the reactivity of the metallated species is also reported.