207561-99-7Relevant articles and documents
Asymmetric direct α-hydroxylation of β-Oxo esters by phase-transfer catalysis using chiral quaternary ammonium salts
Lian, Mingming,Li, Zhi,Du, Jian,Meng, Qingwei,Gao, Zhanxian
supporting information; experimental part, p. 6525 - 6530 (2011/02/25)
The first enantioselective direct α-hydroxylation of β-oxo esters was developed by using phase-transfer catalysis. 1-Indanone-derived 1-adamantyl (1-Ad) β-oxo esters, in the presence of commercially available cumyl hydroperoxide and a cinchonine-based ammonium salt, resulted in the corresponding products with 69-91 % yield and 65-74 % ee. The reaction had also been successfully scaled-up to a gram quantity, and a similar yield was obtained without loss of the enantioselectivity. Copyright
