207612-93-9Relevant articles and documents
Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages
Dubowchik, Gene M,Radia, Shilpa,Mastalerz, Harold,Walker, Michael A.,Firestone, Raymond A.,Dalton King, H.,Hofstead, Sandra J.,Willner, David,Lasch, Shirley J.,Trail, Pamela A.
, p. 1529 - 1532 (2007/10/03)
Bivalent doxorubicin (DOX)-dipeptides (16a-c) were prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates. Conjugate 18b demonstrated antigen-s