207615-86-9

Basic information

• Product Name: (R)-3-tert-Butoxycarbonylamino-4-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-butyric acid benzyl ester
• Synonyms: (R)-3-tert-Butoxycarbonylamino-4-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-butyric acid benzyl ester
• CAS NO: 207615-86-9
• Molecular Weight: 444.918
• Mol File: 207615-86-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3-tert-Butoxycarbonylamino-4-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-butyric acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-tert-Butoxycarbonylamino-4-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-butyric acid benzyl ester(207615-86-9)
• EPA Substance Registry System: (R)-3-tert-Butoxycarbonylamino-4-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-butyric acid benzyl ester(207615-86-9)

Safety Data

• Hazardous Substances Data: 207615-86-9(Hazardous Substances Data)

Upstream product

• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 182748-72-7 (R)-3-((tert-butoxycarbonyl)amino)-4-hydroxybutyric acid benzyl ester 
• 52133-67-2 ethyl 2-cyano-4,4-diethoxybutyrate 
• 3680-71-5 7-deazahypoxanthine 
• 7400-05-7 6-amino-5-(2,2-diethoxy)-2-mercaptopyrimidine-4-ol 

Downstream Products

• 207615-87-0 (R)-4-(4-Azido-pyrrolo[2,3-d]pyrimidin-7-yl)-3-tert-butoxycarbonylamino-butyric acid benzyl ester 

Relevant articles and documents

β-Homoalanyl-PNA: A Special Case of β-Peptides with β-Sheet-Like Backbone Conformation; Organization in Higher Ordered Structures

Although β-homoalanyl peptide nucleic acid oligomers possess a β-peptide backbone, they contain nucleobases in their side chains and are thus an interesting special case of β-peptides. These nucleobases are mainly responsible for the formation of secondary structures through base pairing and stacking. We have investigated the pairing properties of β-homoalanyl-PNA oligomers using adenine and 7-carbaadenine. Simple model studies indicate the existence of Watson-Crick and Hoogsteen pairing planes as an intrinsic structural feature of purinyl β-PNA. As a consequence, the adeninyl-β-PNA hexamer and pentamer form higher ordered structures and the 7-carbaadenine-β-PNA hexamer, which lacks a Hoogsteen pairing site, pairs as a double strand. The synthesis of adeninyl and carbaadeninyl β-nucleoamino acids and their oligomerization is described. Pairing mode and strand orientation were investigated through experiment and simple model studies. In the context of β-peptides the β-PNA oligomers for the most part tend to exist as double strands and prefer the extended β-sheet-like backbone conformation which provides an interesting structure motif in addition to the 31-helix observed for β-peptides.