20767-00-4

Basic information

• Product Name: N-Acetyl-3,5-dinitro-L-tyrosine
• Synonyms: N-ACETYL-3,5-DINITRO-L-TYROSINE;3,5-DINITROACETYL-L-TYROSINE;AC-3,5-DINITRO-TYR-OH;ACETYL-3,5-DINITRO-4-HYDROXY-L-PHENYLALANINE;ACETYL-3,5-DINITRO-L-TYROSINE;N-acetyl-3-5-dinitro-L-tyrosine*crystalline;Ac-Tyr(3,5-NO2)-OH;2-(Acetylamino)-3-(4-hydroxy-3,5-dinitrophenyl)propanoic acid
• CAS NO: 20767-00-4
• Molecular Formula: C11H11N3O8
• Molecular Weight: 313.22
• Product Categories: Tyrosine [Tyr, Y];A - H;Amino Acids;Modified Amino Acids
• Mol File: 20767-00-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 189-190 °C
• Boiling Point: 583.17 °C at 760 mmHg
• Flash Point: 306.49 °C
• Appearance: /
• Density: 1.608 g/cm³
• Vapor Pressure: 1.92E-14mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C
• PKA: 2.80±0.10(Predicted)
• CAS DataBase Reference: N-Acetyl-3,5-dinitro-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-3,5-dinitro-L-tyrosine(20767-00-4)
• EPA Substance Registry System: N-Acetyl-3,5-dinitro-L-tyrosine(20767-00-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 20767-00-4(Hazardous Substances Data)

Usage

Description

N-Acetyl-3,5-dinitro-L-tyrosine is a synthetic compound derived from the modification of the amino acid L-tyrosine. It is characterized by the addition of an acetyl group and two nitro groups at the 3 and 5 positions, respectively. N-Acetyl-3,5-dinitro-L-tyrosine is known for its ability to inhibit the enzyme pepsin, which plays a crucial role in the digestion process.

Uses

Used in Pharmaceutical Research:
N-Acetyl-3,5-dinitro-L-tyrosine is used as a pepsin inhibitor for studying the hydrolysis actions of the substrate-binding region of the active center of the enzyme. This application is particularly relevant in the field of pharmaceutical research, where understanding the mechanisms of enzyme inhibition can lead to the development of new drugs and therapies.
Used in Digestive Health Research:
In the field of digestive health research, N-Acetyl-3,5-dinitro-L-tyrosine is used to investigate the role of pepsin in the breakdown of proteins in the stomach. By inhibiting pepsin, researchers can gain insights into the digestive process and potentially develop treatments for conditions related to improper protein digestion.
Used in Drug Development:
N-Acetyl-3,5-dinitro-L-tyrosine is also used in drug development as a potential therapeutic agent for conditions where pepsin overactivity or improper regulation may contribute to disease progression. By targeting pepsin inhibition, this compound could potentially be used to treat gastric ulcers, gastritis, or other gastrointestinal disorders.

InChI:InChI=1/C11H11N3O8/c1-5(15)12-7(11(17)18)2-6-3-8(13(19)20)10(16)9(4-6)14(21)22/h3-4,7,16H,2H2,1H3,(H,12,15)(H,17,18)/t7-/m1/s1

Upstream product

• 537-55-3 N-acetyl-L-tyrosine 
• 17360-11-1 NSC 80662 
• 108-24-7 acetic anhydride 
• 60-18-4 L-tyrosine 

Downstream Products

• 83290-90-8 3.5-dinitro-O'-methyl-N-acetyl-L-thyronine ethyl ester 
• 83249-56-3 N-acetyl-O-(4-methoxyphenyl)-3,5-diiodo-L-tyrosine ethyl ester 
• 440667-78-7 3.5-diamino-O'-methyl-N-acetyl-L-thyronine ethyl ester 
• 94345-95-6 2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid 
• 97432-47-8 3.5-bis-acetylamino-O'-methyl-N-acetyl-L-thyronine ethyl ester 
• 29358-99-4 N-acetyl-3,5-dinitro-L-tyrosine ethyl ester