207737-97-1

Basic information

• Product Name: Taurodeoxycholic acid sodium salt monohydrate
• Synonyms: TAURODEOXYCHOLIC ACID SODIUM SIGMAULTRA;2-([3α,12α-dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid;Taurodeoxycholic acid hydrate sodium salt, 2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid;N-(Deoxycholyl)taurine sodium salt, Taurodeoxycholic acid sodium salt, 3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt;Sodium taurodeoxycholate hydrate,2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate;2-[[(3alpha,5beta,12alpha)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid monosodium salt hydrate;Ethanesulfonic acid,2-[[(3a,5b,12a)-3,12-dihydroxy-24-oxocholan-24-yl]aMino]-, sodiuM salt, hydrate (1:1:);3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt
• CAS NO: 207737-97-1
• Molecular Formula: C26H44NO6S.Na.H2O
• Molecular Weight: 539.705
• EINECS: 805-952-8
• Mol File: 207737-97-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 168 °C (dec.)(lit.)
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: H2O: soluble0.5M, clear, colorless to faintly yellow
• BRN: 3901204
• CAS DataBase Reference: Taurodeoxycholic acid sodium salt monohydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Taurodeoxycholic acid sodium salt monohydrate(207737-97-1)
• EPA Substance Registry System: Taurodeoxycholic acid sodium salt monohydrate(207737-97-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 207737-97-1(Hazardous Substances Data)

Usage

Description

Taurodeoxycholic acid sodium salt monohydrate is a bile salt-related, anionic detergent that is naturally present in the small bowel. It is used for the isolation of membrane proteins, including inner mitochondrial membrane proteins, and has been studied for its effects on lipid bilayer membranes and polymorphic behavior in protein-surfactant mixtures. Additionally, it is a hydrate form of sodium taurodeoxycholate, which has been shown to rescue human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.

Uses

Used in Pharmaceutical Industry:
Taurodeoxycholic acid sodium salt monohydrate is used as a pharmaceutical agent for its potential role in rescuing human colon cancer cells from apoptosis. It achieves this by activating EGFR-dependent PI3K/Akt signaling, which may have implications for cancer treatment and cell survival.
Used in Biotechnology and Research:
Taurodeoxycholic acid sodium salt monohydrate is used as a detergent for the isolation of membrane proteins, particularly inner mitochondrial membrane proteins. Its anionic nature and detergent properties make it suitable for studying the structure and function of these proteins.
Used in Membrane Biophysics:
Taurodeoxycholic acid sodium salt monohydrate is used as a research tool to investigate the effects of submicellar concentrations of bile salts on lipid bilayer membranes. This helps in understanding the interactions between bile salts and biological membranes, which is crucial for various biophysical and cellular processes.
Used in Protein-Surfactant Interactions:
Taurodeoxycholic acid sodium salt monohydrate is used in studies to explore the polymorphic behavior in protein-surfactant mixtures. This knowledge can be applied to develop a better understanding of the structural changes and stability of proteins in the presence of surfactants, which is important for various biotechnological and pharmaceutical applications.

InChI:InChI=1/C26H45NO6S.Na.H2O/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;;/m1../s1