207744-21-6Relevant articles and documents
Asymmetric reduction of (Z)-α,β-dehydrotryptophanyl-containing biological peptides with sulfur functionality. Influence of substrate on stereoselectivity
Hammadi, Akli,Lam, Hubert,Gondry, Muriel,Ménez, André,Genet, Roger
, p. 4473 - 4477 (2000)
Two (Z)-α,β-dehydropentapeptides, Boc-βAla-Δ(Z) Trp-Met-Asp-Phe-NH2 1 and Boc-AlaΔ(Z)-Trp-NLeu-Asp-Phe-NH2 2, have been synthesized by enzymatic α,β-dehydrogenation, and then submitted to rhodium-catalysed asymmetric hydrogenation. The influence of the S-atom on the rate and stereoselectivity of the reduction have been investigated. (C) 2000 Elsevier Science Ltd.