20776-55-0

Basic information

• Product Name: 2-amino-3-iodo-benzoic acid
• Synonyms: 2-amino-3-iodo-benzoic acid;Anthranilic acid, 3-iodo-
• CAS NO: 20776-55-0
• Molecular Formula: C₇H₆INO₂
• Molecular Weight: 263.03
• Mol File: 20776-55-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 137 °C
• Boiling Point: 366.5 °C at 760 mmHg
• Flash Point: 175.5 °C
• Appearance: /
• Density: 2.082g/cm³
• Vapor Pressure: 5.13E-06mmHg at 25°C
• Refractive Index: 1.728
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.59±0.10(Predicted)
• CAS DataBase Reference: 2-amino-3-iodo-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3-iodo-benzoic acid(20776-55-0)
• EPA Substance Registry System: 2-amino-3-iodo-benzoic acid(20776-55-0)

Safety Data

• Hazardous Substances Data: 20776-55-0(Hazardous Substances Data)

Usage

General Description

2-amino-3-iodo-benzoic acid is a chemical compound with the molecular formula C7H6INO2. It is an aromatic carboxylic acid derivative with a 2-amino group and a 3-iodo substituent on the benzene ring. 2-amino-3-iodo-benzoic acid is commonly used in organic synthesis and as a building block for pharmaceuticals. It has potential applications in the field of medicinal chemistry, especially in the development of new drugs and pharmaceutical formulations. 2-amino-3-iodo-benzoic acid may also exhibit biological activity and has been studied for its potential therapeutic properties. Overall, it is a versatile and important chemical with various uses in the pharmaceutical and chemical industries.

InChI:InChI=1/C7H6INO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,9H2,(H,10,11)

Upstream product

• 20780-78-3 7-iodoisatin 
• 99-05-8 meta-aminobenzoic acid 
• 618-51-9 3-Iodobenzoic acid 
• 117500-16-0 2'-hydroxyimino-2-iodoacetanilide 
• 118-92-3 anthranilic acid 

Downstream Products

• 85063-06-5 2-(o-methyl phenoxymethyl)-8-iodo anthranil 
• 83793-87-7 2-(3,5-Dimethylphenoxymethyl)-8-iodoanthranil 
• 68501-67-7 8-Iodo-2-phenyl-benzo[d][1,3]oxazin-4-one 
• 85063-05-4 8-Iodo-2-phenoxymethyl-benzo[d][1,3]oxazin-4-one 
• 118-92-3 anthranilic acid 
• 679426-09-6 3-iodo-2-(pyrrol-1-yl)benzoic acid 
• 913286-73-4 benzyl 2-amino-3-iodobenzoate 
• 679426-10-9 ethyl 3-iodo-2-(pyrrol-1-yl)benzoate 
• 85063-10-1 (8-Iodo-4-oxo-2-phenoxymethyl-4H-quinazolin-3-yl)-acetic acid 
• 85063-11-2 2-(o-methyl phenoxymethyl)-3-carboxymethyl-8-iodo-(3H)-4-quinazolone 
• 85063-21-4 8-Iodo-3-(2-morpholin-4-yl-2-oxo-ethyl)-2-phenoxymethyl-3H-quinazolin-4-one 
• 83793-66-2 [2-(3,5-Dimethyl-phenoxymethyl)-8-iodo-4-oxo-4H-quinazolin-3-yl]-acetic acid 
• 74461-38-4 3-(1H-Benzoimidazol-2-ylmethyl)-8-iodo-2-phenyl-3H-quinazolin-4-one 
• 83793-65-1 (R)-2-[2-(3,5-Dimethyl-phenoxymethyl)-8-iodo-4-oxo-4H-quinazolin-3-yl]-propionic acid 

Relevant articles and documents

A High-Throughput Assay for Arylamine Halogenation Based on a Peroxidase-Mediated Quinone-Amine Coupling with Applications in the Screening of Enzymatic Halogenations

Arylhalides are important building blocks in many fine chemicals, pharmaceuticals and agrochemicals, and there has been increasing interest in the development of more "green" halogenation methods based on enzyme catalysis. However, the screening and development of new enzymes for biohalogenation has been hampered by a lack of high-throughput screening methods. Described herein is the development of a colorimetric assay for detecting both chemical and enzymatic arylamine halogenation reactions in an aqueous environment. The assay is based on the unique UV/Vis spectrum created by the formation of an ortho-benzoquinone-amine adduct, which is produced by the peroxidase-catalysed benzoquinone generation, followed by Michael addition of either a halogenated or non-halogenated arylamine. This assay is sensitive, rapid and amenable to high-throughput screening platforms. We have also shown this assay to be easily coupled to a flavin-dependent halogenase, which currently lacks any convenient colorimetric assay, in a "one-pot" workflow.

METHOD FOR PRODUCING 2-AMINO-5-IODOBENZOIC ACID

A method for producing 2-amino-5-iodobenzoic acid which comprises bringing 2-aminobenzoic acid (A) and molecular iodine (B) into reaction with each other in the liquid phase in the presence of an oxidizing agent. Hydrogen peroxide is preferable as the oxidizing agent. This method does not require a step for purifying 2-amino-5-iodobenzoic acid or a step for recovering iodine, and 2-amino-5-iodobenzoic acid having excellent quality can be produced economically advantageously with a great yield. The product can be advantageously used as an intermediate for drugs, an agricultural chemical and a raw material for functional chemicals.