20777-79-1

Basic information

• Product Name: L-Leucine, N-[(phenylmethoxy)carbonyl]-L-leucyl-, hydrazide
• CAS NO: 20777-79-1
• Molecular Formula: C20H32N4O4
• Molecular Weight: 392.498
• Mol File: 20777-79-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[(phenylmethoxy)carbonyl]-L-leucyl-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[(phenylmethoxy)carbonyl]-L-leucyl-, hydrazide(20777-79-1)
• EPA Substance Registry System: L-Leucine, N-[(phenylmethoxy)carbonyl]-L-leucyl-, hydrazide(20777-79-1)

Safety Data

• Hazardous Substances Data: 20777-79-1(Hazardous Substances Data)

Upstream product

• 2666-93-5 (S)-Leu-OMe 
• 2018-66-8 Z-Leu-OH 
• 97921-57-8 N-Carbobenzyloxyleucyl-N'-L-leucyl-hydrazin 
• 21687-95-6 Benzyloxycarbonyl-L-leucyl-L-leucin-ethylester 
• 3504-37-8 Cbz-L-Leu-L-Leu-OMe 

Downstream Products

• 1619233-22-5 benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-6-methyl-3-methylene-2-oxoheptan-4-yl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate 
• 1619233-20-3 benzyl ((S)-1-(((S)-1-(((S)-2,6-dimethyl-3-oxohept-1-en-4-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate 
• 1619233-41-8 benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-3-methyl-1-((2S, 2'R)-2'-methyl-[2,2'-bioxiran]-2-yl)butyl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate 
• 1619233-19-0 benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-3-methyl-1-((2R, 2'R)-2'-methyl-[2,2'-bioxiran]-2-yl)butyl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate 
• 1228083-42-8 Cbz-Leu₂-(R)-5-amino-5,6-dihydro-pyran-2-one 
• 1228083-41-7 Cbz-Leu₂-leucinyl vinyl 1-adamantylmethylsulfone 
• 1228083-39-3 Cbz-Leu₂-leucinyl vinyl diphenylphosphinoxide 
• 1228083-37-1 (S,E)-4-Cbz-Leu₂-amino-6-methylhept-2-enenitrile 
• 1228083-46-2 Cbz-Leu₂-(S,E)-5-amino-7-methyloct-2-en-4-one 
• 1228083-45-1 Cbz-Leu₂-4-leucinyl-furan-2(5H)-one 
• 1228083-44-0 Cbz-Leu₂-3-leucinylfuran-2(5H)-one 
• 1228083-43-9 Cbz-Leu₂-(5R,6R)-5-amino-6-methyl-5,6-dihydropyran-2-one 
• 111196-07-7 3-carboxypropionylleucyl-leucyl-alanine p-nitroanilide 

Relevant articles and documents

Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

Aza-peptide aldehydes and ketones are a new class of reversible protease inhibitors that are specific for the proteasome and clan CD cysteine proteases. We designed and synthesised aza-Leu derivatives that were specific for the chymotrypsin-like active si

Aza-peptide epoxides: A new class of inhibitors selective for clan CD cysteine proteases

Aza-peptide epoxides, a new class of irreversible protease inhibitors, are specific for the clan CD cysteine proteases. The inhibitors have second-order rate constants up to 105 M-1 s-1, with the most potent epoxides having the S,S stereochemistry. The aza-Asn derivatives are effective legumain inhibitors, while the aza-Asp epoxides were specific for caspases. The inhibitors have little or no inhibition with other proteases such as chymotrypsin, papain, or cathepsin B.

Synthesis and inhibiting activities of 1-peptidyl-2-haloacetyl hydrazines toward cathepsin B and calpains

Twenty-four 1-peptidyl-2-haloacetyl hydrazines which can be considered azapeptide halomethanes were synthesized and tested as models of cathepsin B, calpain I and calpain II inhibitors.Reagents designed for cathepsin B inactivation include Z-Tyr, Z-Tyr(I)