207797-05-5

Basic information

• Product Name: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole
• Synonyms: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole
• CAS NO: 207797-05-5
• Molecular Formula: C₁₀H₇F₃N₂
• Molecular Weight: 212.18
• Mol File: 207797-05-5.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 240.4 °C at 760 mmHg
• Flash Point: 99.2 °C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.0589mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole(207797-05-5)
• EPA Substance Registry System: 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole(207797-05-5)

Safety Data

• Hazardous Substances Data: 207797-05-5(Hazardous Substances Data)

Usage

Description

1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole is a versatile organic chemical compound with the molecular formula C10H7F3N2. It belongs to the class of pyrazoles, which are heterocyclic aromatic compounds featuring a five-membered ring with two nitrogen atoms. This particular compound is distinguished by the presence of a trifluoromethyl group and a phenyl group attached to the pyrazole ring. The trifluoromethyl group imparts unique chemical and physical properties, while the phenyl group enhances the compound's aromaticity and reactivity. These characteristics make 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole a valuable compound for research and development across various industries.

Uses

Used in Pharmaceutical Industry:
1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole is utilized as a key intermediate in the synthesis of pharmaceuticals for its potential medicinal properties. The trifluoromethyl group can impart metabolic stability and lipophilicity, which are desirable characteristics for drug development.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole serves as a building block for the creation of novel agrochemicals. Its unique structure can contribute to the development of new pesticides or herbicides with improved efficacy and selectivity.
Used in Materials Science:
1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole is employed in materials science for the development of advanced materials with tailored properties. 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole's ability to influence the chemical and physical characteristics of materials makes it suitable for applications in areas such as polymers, coatings, and composites.
Overall, 1-(4-(Trifluoromethyl)phenyl)-1H-pyrazole is a multifaceted chemical compound with a broad spectrum of applications across different industries, including pharmaceuticals, agrochemicals, and materials science. Its unique structure and properties make it a promising candidate for further research and development.

InChI:InChI=1/C10H7F3N2/c11-10(12,13)8-2-4-9(5-3-8)15-7-1-6-14-15/h1-7H

Upstream product

• 288-13-1 NH-pyrazole 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 98-56-6 4-chlorobenzotrifluoride 
• 455-13-0 4-Iodobenzotrifluoride 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 2923-56-0 4-(trifluoromethyl)phenylhydrazine hydrochloride 
• 402-44-8 4-Fluorobenzotrifluoride 

Downstream Products

• 861162-10-9 2-ethyl-1-{1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}butan-1-ol 
• 1260140-73-5 4,5-diphenyl-7-trifluoromethylpyrazolo[1,5-a]quinoline 
• 1314002-55-5 5-iodo-1-[2-iodo-4-(trifluoromethyl)phenyl]-1H-pyrazole 
• 1426830-32-1 1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carbaldehyde 
• 1443331-02-9 C₁₇H₁₇N₃O₂S 
• 1007678-92-3 C₁₇H₁₄F₃N₃O₂S 
• 1379667-34-1 N-[2-(1H-pyrazol-1-yl)phenyl]-4-methylbenzenesulfonamide 

Relevant articles and documents

INHIBITOR COMPOUNDS

The disclosure relates to heterocyclic compounds and methods for their preparation. The disclosure provides compounds that may have beneficial therapeutic activity in the treatment of a disease or condition mediated by excessive or otherwise undesirable Des1 and/or fibrotic activity.

L -(-) -Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles

l-(-)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.

Tunable Emission Color of Iridium(III) Complexes with Phenylpyrazole Derivatives as the Main Ligands for Organic Light-Emitting Diodes

Seven cyclometalated iridium(III) complexes Ir1-Ir7 based on phenylpyrazole derivatives as main ligands and tetraphenylimidodiphosphinate (tpip) as the ancillary ligand were synthesized and fully characterized. The proligands of 1-[4-(trifluoromethyl)phenyl]-1H-pyrazole (cf3ppz, 2a), substituted phenyl-2H-indazole {2-phenyl-2H-indazole (h-1-pidz, 2b), 2-(4-fluorophenyl)-2H-indazole (f-1-pidz, 2c), and 2-[4-(trifluoromethyl)phenyl]-2H-indazole (cf3-1-pidz, 2d)}, and substituted phenyl-1H-indazole {1-phenyl-1H-indazole (h-7-pidz, 2e), 1-(4-fluorophenyl)-1H-indazole (f-7-pidz, 2f), and 1-[4-(trifluoromethyl)phenyl]-1H-indazole (cf3-7-pidz, 2g)} were prepared with good yields. The emission maxima of all Ir(III) complexes can be tuned from 453 to 576 nm with different photoluminescence quantum yields (10.4-70.9%) by varying the type of substituent on the different main ligand frameworks. The organic light-emitting diodes using Ir(III) complexes as the emitters with blue, bluish-green, and yellow colors exhibit a maximum current efficiency and an external quantum efficiency of 39.2 cd A-1 and 14.8%, respectively.