20781-86-6

Basic information

• Product Name: 2-Chloro-N-(2,6-diisopropyl-phenyl)-acetamide
• Synonyms: 2-Chloro-N-(2,6-diisopropyl-phenyl)-acetamide;N-[2,6-bis(propan-2-yl)phenyl]-2-chloroacetamide
• CAS NO: 20781-86-6
• Molecular Formula: C₁₄H₂₀ClNO
• Molecular Weight: 253.77
• Mol File: 20781-86-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-N-(2,6-diisopropyl-phenyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-(2,6-diisopropyl-phenyl)-acetamide(20781-86-6)
• EPA Substance Registry System: 2-Chloro-N-(2,6-diisopropyl-phenyl)-acetamide(20781-86-6)

Safety Data

• Hazardous Substances Data: 20781-86-6(Hazardous Substances Data)

Upstream product

• 24544-04-5 2,6-diisopropylbenzenamine 
• 79-04-9 chloroacetyl chloride 
• 593-71-5 Chloroiodomethane 
• 28178-42-9 2,6-diisopropylphenyl isocyanate 

Downstream Products

• 116855-48-2 2-(diethylamino)-N-<2,6-bis(1-methylethyl)phenyl>acetamide 
• 176495-54-8 N-(2,6-diisopropylphenyl)-2-phenacylthioacetamide 
• 909030-52-0 2-azido-N-(2',6'-diisopropylphenyl)acetamide 
• 888705-45-1 1-(2',6'-diisopropylphenyl)-4,5-dihydro-1H-imidazole 
• 888705-44-0 N¹-(2,6-diisopropylphenyl)ethane-1,2-diamine 
• 909030-90-6 N-(2,6-diisopropylphenyl)-N'-(2-methoxynaphth-1-yl)ethylenediamine 
• 116855-49-3 N,N-diethyl-N'-<2,6-bis(1-methylethyl)phenyl>-1,2-ethanediamine 
• 116855-34-6 N-<2-(diethylamino)ethyl>-N-<2,6-bis(1-methylethyl)phenyl>-4-<(methylsulfonyl)amino>benzamide 
• 1129865-64-0 N-(2,6-diisopropylphenyl)-2-(2,4-dioxo-1-phenyl-1,3-diazaspiro[4.4]non-3-yl)acetamide 
• 1129865-68-4 N-(2,6-diisopropylphenyl)-2-(4-oxo-1-phenyl-1,3-diazaspiro[4.5]dec-3-yl)-acetamide 
• 1128305-31-6 N-(2,6-diisopropylphenyl)-2-[(1-phenylaminocyclohexylmethyl)amino]-acetamide 

Relevant articles and documents

Versatile Bulky N,N′,N′-Substituted 1,2-Ethanediamine Ligands and Their Lithium, Aluminium, and Gallium Derivatives

Sterically demanding N,N′,N′-substituted 1,2-ethanediamine ligands have been prepared from commercially available starting materials by applying a facile one-step procedure. These ligands offer advantages compared to known systems: a suppressed delocalization due to the saturated backbone inhibits a noninnocent behaviour and the low symmetry of the related metal complexes makes them potential candidates for asymmetric catalysis. The ligands are readily transformed into the corresponding lithium derivatives 4, which in turn act as starting materials to access the corresponding aluminium and gallium dichlorides 5 and 6, respectively. In addition, deprotonation by Al(CH3)3gives rise to the related dimethylalane 7. All main-group element compounds have been studied by means of single X-ray crystallography and spectroscopic methods.

Addition of lithium carbenoids to isocyanates: A direct access to synthetically useful N-substituted 2-haloacetamides

The addition of lithium carbenoids to isocyanates provides a versatile access to N-substituted 2-haloacetamides: the reaction tolerates the presence of variously functionalized substituents on the nitrogen atom, including sterically demanding ones and reactive halogens. No erosion of the enantiopurity was observed in the case of optically active isocyanates. One of the substrates prepared has been employed in Charette's type chemoselective addition of a Grignard reagent to access an α-chloroketone.

NOVEL N-PHENYLACETAMIDE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM

The present invention relates to novel compounds of general formula (I) : and to cosmetic and pharmaceutical compositions containing such a compound.