2079-53-0Relevant articles and documents
Safe, convenient ortho-Claisen thermal rearrangement using a flow reactor
Rincon, Juan A.,Barberis, Mario,Gonzalez-Esguevillas, Maria,Johnson, Martin D.,Niemeier, Jeffry K.,Sun, Wei-Ming
, p. 1428 - 1432 (2011)
The [3,3] Claisen rearrangement is a well-known reaction that has been very useful for the synthesis of o-allyl phenols. The thermally induced rearrangement could present safety and operational issues at large batch scale. Herein, we report a process that
Total Synthesis and Anti-inflammatory Evaluation of Penchinone A and Its Structural Analogues
Oh, Yongguk,Jang, Yeon Jeong,Jeon, Mijin,Kim, Hyung Sik,Kwak, Jong Hwan,Chung, Kyu Hyuck,Pyo, Suhkneung,Jung, Young Hoon,Kim, In Su
, p. 11566 - 11572 (2017)
The first total synthesis and biological evaluation of penchinone A and its structural analogues are described. The key steps for the preparation of penchinone A derivatives involve the oxime-directed palladium(II)-catalyzed oxidative acylation, Claisen r
Synthesis, molecular modelling studies of indolyl chalcone derivatives and their antimalarial activity evaluation
Jyoti,Gaur, Rashmi,Kumar, Yogesh,Cheema, Harveer Singh,Kapkoti, Deepak Singh,Darokar, Mahendra P.,Khan, Feroz,Bhakuni, Rajendra Singh
, p. 3261 - 3268 (2019/12/11)
Twenty one chalcone derivatives were synthesized using Claisen-Schmidt condensation, their antimalarial activity against Plasmodium falciparum was determined and quantitative structure–activity relationship (QSAR) was developed. Condensation of substituted acetophenones with various aromatic aldehydes at room temperature gave chalcones in 75–96% yield. Chalcones are secondary metabolites of terrestrial plants, precursors for the biosynthesis of flavonoids and exhibit various biological activities. Antiplasmodial IC50 (half-maximal inhibitory concentration) activity of a compound against malaria parasites in?vitro provides a good first screen for identifying the antimalarial potential of the compound. The most active compound was Trans-3-(1H-indol-3-yl)-1-(2’-hydroxyphenyl)-2-propen-1-one(1b) with IC50 of 2.1 μM/L. Molecular mechanism was explored through in silico docking & ADMET studies for the active compounds.
Highly regioselective O-allylation of phenol derivatives using MMZCu(I)Y catalyst
Thangapriya, Cheirmakani,Ilaamirthamani, Simsonrubarathinam,Kumarraja, Mayilvasagam
, p. 361 - 367 (2019/12/11)
A clean and effective method has been developed for the regioselective of O-allylation of phenol derivatives using a recyclable Cu(I)-exchanged multi-size porous material. Ease of preparation of catalyst through simple solid-state exchange and its compatibility in producing excellent amount of O-allylated products and a plausible mechanistic pathway for the regioselectivity are highlighted. This reported procedure is not requiring any external stabilizing ligand for Cu(I) species and further purification of products.