20800-27-5

Basic information

• Product Name: N-Phenyl-benzimidoyl-isothiocyanat
• Synonyms: N-Phenyl-benzimidoyl-isothiocyanat
• CAS NO: 20800-27-5
• Molecular Weight: 238.313
• Mol File: 20800-27-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-Phenyl-benzimidoyl-isothiocyanat(CAS DataBase Reference)
• NIST Chemistry Reference: N-Phenyl-benzimidoyl-isothiocyanat(20800-27-5)
• EPA Substance Registry System: N-Phenyl-benzimidoyl-isothiocyanat(20800-27-5)

Safety Data

• Hazardous Substances Data: 20800-27-5(Hazardous Substances Data)

Upstream product

• 540-72-7 sodium thiocyanide 
• 4903-36-0 N-phenyl-benzimidoyl chloride 
• 93-98-1 N-phenyl benzoyl amide 
• 62-53-3 aniline 
• 98-88-4 benzoyl chloride 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 128652-15-3 Pyrrolidine-1-carbothioic acid {phenyl-[(E)-phenylimino]-methyl}-amide 
• 128652-16-4 1,1-Dimethyl-3-{phenyl-[(E)-phenylimino]-methyl}-thiourea 
• 20800-34-4 N-(N-Phenyl-benzimidoyl)-N'-phenyl-thioharnstoff 
• 1281681-13-7 1-(4-morpholinethyl)-3-(N-phenylbenzimidoyl)thiourea 
• 1355575-68-6 3-(N-phenylbenzimidoyl)-1-(2-pyridyl)thiourea 
• 1281680-93-0 3-(N-phenylbenzimidoyl)-1-(3-pyridylmethyl)thiourea 
• 1281681-55-7 5-imino-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole hydrobromide 
• 1281681-33-1 5-(4-morpholinethylimino)-2,3-diphenyl-2,5-dihydro-1,2,4-thiadiazole dihydrobromide 
• 69909-49-5 2,3-diphenyl-5-phenylimino-2,5-dihydro-1,2,4-thiadiazole 
• 1281680-95-2 1-ethoxycarbonylmethyl-3-(N-phenylbenzimidoyl)thiourea 
• 20800-35-5 1-cyclohexyl-3-(N-phenylbenzimidoyl)thiourea 
• 1281681-03-5 1-(2-hydroxyethyl)-3-(N-4-methoxyphenylbenzimidoyl)thiourea 
• 1281680-96-3 1-(2-hydroxyethyl)-3-(N-phenylbenzimidoyl)thiourea 
• 1281680-97-4 1-pentyl-3-(N-phenylbenzimidoyl)thiourea 

Relevant articles and documents

5-Imino-1,2,4-thiadiazoles: First small molecules As substrate competitive inhibitors of glycogen synthase kinase 3

Cumulative evidence strongly supports that glycogen synthase kinase-3 (GSK-3) is a pathogenic molecule when it is up-dysregulated, emerging as an important therapeutic target in severe unmet human diseases. GSK-3 specific inhibitors might be promising effective drugs for the treatment of devastating pathologies such as neurodegenerative diseases, stroke, and mood disorders. As GSK-3 has the ability to phosphorylate primed substrates, small molecules able to bind to this site should be perfect drug candidates, able to partially block the activity of the enzyme over some specific substrates. Here, we report substituted 5-imino-1,2,4-thiadiazoles as the first small molecules able to inhibit GSK-3 in a substrate competitive manner. These compounds are cell permeable, able to decrease inflammatory activation and to selectively differentiate neural stem cells. Overall, 5-imino-1,2,4-thiadiazoles are presented here as new molecules able to decrease neuronal cell death and to increase endogenous neurogenesis blocking the GSK-3 substrate site

Amidine derived 1,3-diazabuta-1,3-dienes as potential antibacterial and antifungal agents

Several 1-aryl-2-phenyl-4-piperidino-4-thioalkyl-1,3-diazabuta-1,3-dienes were prepared by the treatment of N-arylimino isothiocyanate with piperidine followed by S-alkylation with alkyl iodides in the presence of dry acetone and potassium hydroxide. The