208167-83-3 Usage
Description
N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt is a chemical compound that features a piperazine core with a chloroethyl group and a Boc-protecting group. It is a versatile intermediate in organic synthesis and has potential applications in the development of pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its chloroethyl moiety can be utilized in the synthesis of nitrogen mustards, which are known for their anticancer properties.
Used in Anticancer Research:
In a study of anticancer activity of dihydroxyanthrathiazolediones, N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt is used as a key component in the synthesis of these compounds. The dihydroxyanthrathiazolediones have shown promising anticancer activity, making this compound an important part of ongoing research in cancer treatment.
Used in the Synthesis of BEL-7404 Liver Cancer Cells:
N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt is used in the direct condensation of chloroalkyl piperazine, nitrogen mustard benzaldehyde, and pyrrole to produce BEL-7404 liver cancer cells. N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt has demonstrated anticancer activity, making it a valuable tool in the development of new cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 208167-83-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,8,1,6 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 208167-83:
(8*2)+(7*0)+(6*8)+(5*1)+(4*6)+(3*7)+(2*8)+(1*3)=133
133 % 10 = 3
So 208167-83-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H21ClN2O2/c1-11(2,3)16-10(15)14-8-6-13(5-4-12)7-9-14/h4-9H2,1-3H3
208167-83-3Relevant articles and documents
Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents
Liang, Yu-Kun,Yue, Zhi-Zhou,Li, Jia-Xin,Tan, Cun,Miao, Ze-Hong,Tan, Wen-Fu,Yang, Chun-Hao
, p. 505 - 515 (2014)
Two series of novel 2-substituted 5,7-dihydroxyanthra[2,1-d]thiazole-6,11- dione derivatives from natural rhein were designed, synthesized and evaluated for their antitumour activities against human cancer cell lines A549 and HeLa in vitro.
N-(3-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PHENYL)BENZAMIDE DERIVATIVES
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Page/Page column 126; 127, (2019/10/23)
The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.
A anthraquinone and thiazole compounds, its preparation method and use thereof
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Paragraph 0155-0157, (2017/08/10)
The invention relates to a compound which takes 5,7-dihydroxyanthraquinone [2,1-d]thiazole as a mother nucleus, which has a following general formula, and relates to a preparation method and an application of the compound in an antitumor drug. The compound takes a traditional natural product rheinic acid as an initial raw material, and a series of compound with high antineoplastic activity is synthesized through mild reaction condition. The antitumor activity in vitro of the preferable compound is stronger by more than 30 times by comparing with rheinic acid.
