208194-63-2

Basic information

• Product Name: (E)-2-Bromo-5-p-tolyl-pent-2-en-4-ynoic acid ethyl ester
• Synonyms: (E)-2-Bromo-5-p-tolyl-pent-2-en-4-ynoic acid ethyl ester
• CAS NO: 208194-63-2
• Molecular Weight: 293.16
• Mol File: 208194-63-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-Bromo-5-p-tolyl-pent-2-en-4-ynoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-Bromo-5-p-tolyl-pent-2-en-4-ynoic acid ethyl ester(208194-63-2)
• EPA Substance Registry System: (E)-2-Bromo-5-p-tolyl-pent-2-en-4-ynoic acid ethyl ester(208194-63-2)

Safety Data

• Hazardous Substances Data: 208194-63-2(Hazardous Substances Data)

Upstream product

• 26631-69-6 ethyl (E)-2,3-dibromopropenoate 

Downstream Products

• 208194-67-6 3-Bromo-5-[1-p-tolyl-meth-(Z)-ylidene]-5H-furan-2-one 
• 5567-29-3 3-bromo-6-p-tolyl-pyran-2-one 

Relevant articles and documents

A novel protocol for the stereoselective synthesis of variously substituted (Z)-5-ylidene-5H-furan-2-ones

The Pd(II)- or Ag(I)-catalyzed lactonization of easily available (E)-4- (1-alkynyl)-2-bromopropenoic acids provides (Z)-3-bromo-5-ylidene-5H-furan- 2-ones, 5. These compounds, which represent an unpreviously reported class of (Z)-alkylidenebutenolides, are able to undergo Pd-catalyzed cross-coupling reactions with arylzinc halides, tetraalkylstannanes or alkenylstannanes to provide the corresponding 3-substituted (Z)-5-ylidene-5H-furan-2-ones, 1. The new procedure for the preparation of compounds 1 has been employed in a new synthesis of the butter flavour component bovolide.