2082-28-2Relevant articles and documents
Biomimetic synthesis of Tramadol
Lecerf-Schmidt, Florine,Haudecoeur, Romain,Peres, Basile,Ferreira Queiroz, Marcos Mar?al,Marcourt, Laurence,Challal, Soura,Ferreira Queiroz, Emerson,Sotoing Taiwe, Germain,Lomberget, Thierry,Le Borgne, Marc,Wolfender, Jean-Luc,De Waard, Michel,Robins, Richard J.,Boumendjel, Ahcène
, p. 14451 - 14453 (2015)
Tramadol has recently been isolated from the roots and bark of Nauclea latifolia. A plausible biosynthetic pathway has been proposed and the product-precursor relationship has been probed by 13C position-specific isotope analysis. By further exploring this pathway, we demonstrate that a key step of the proposed pathway can be achieved using mild conditions that mimic in vivo catalysis.
Basic ethers of 1-substituted cycloalkanols. 1
Pallos,Budai,Zolyomi
, p. 1502 - 1505 (2007/10/05)
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